Siddharth Sridhar

Learn More
| The development of a trustworthy smart grid requires a deeper understanding of potential impacts resulting from successful cyber attacks. Estimating feasible attack impact requires an evaluation of the grid’s dependency on its cyber infrastructure and its ability to tolerate potential failures. A further exploration of the cyber–physical relationships(More)
The development of a smarter electric grid will depend on increased deployments of information and communication technology (ICT) to support novel communication and control functions. Unfortunately, this additional dependency also expands the risk from cyber attacks. Designing systemswith adequate cyber security depends heavily on the availability of(More)
Cyber systems play a critical role in improving the efficiency and reliability of power system operation and ensuring the system remains within safe operating margins. An adversary can inflict severe damage to the underlying physical system by compromising the control and monitoring applications facilitated by the cyber layer. Protection of critical assets(More)
Helcococcus kunzii was isolated from a brain abscess in a diabetic patient with cholesteatoma and demonstrated satellitism around Staphylococcus aureus in culture. This is the first reported case of severe central nervous system infection due to H. kunzii and the first description of a satelliting phenotypic variant of this organism.
Zika virus (ZIKV) is unique among human-pathogenic flaviviruses by its association with congenital anomalies and trans-placental and sexual human-to-human transmission. Although the pathogenesis of ZIKV-associated neurological complications has been reported in recent studies, key questions on the pathogenesis of the other clinical manifestations,(More)
Hepatitis E virus (HEV) is the most common cause of acute viral hepatitis worldwide. Originally considered to be restricted to humans, it is now clear that HEV and HEV-like viruses have several animal reservoirs with complex ecology and genetic diversity, as exemplified by the recent discovery of HEV in dromedaries, a previously underestimated reservoir of(More)
Although tuberculosis (TB) is a reemerging disease that affects people in developing countries and immunocompromised populations in developed countries, the current diagnostic methods are far from optimal. Metabolomics is increasingly being used for studies on infectious diseases. We performed metabolome profiling of plasma samples to identify potential(More)
BACKGROUND Hospital outbreaks of epidemiologically important pathogens are usually caused by lapses in infection control measures and result in increased morbidity, mortality, and cost. However, there is no benchmark to compare the occurrence of hospital outbreaks across hospitals. METHODS We implemented proactive infection control measures with an(More)
Melioidosis is an emerging, potentially fatal disease caused by Burkholderia pseudomallei, which requires prolonged antibiotic treatment to prevent disease relapse. However, difficulties in laboratory diagnosis of melioidosis may delay treatment and affect disease outcomes. Isolation of B. pseudomallei from clinical specimens has been improved with the use(More)
Melioidosis, an infection with an expanding geographic range, is extremely rare in neutropenic patients. We report bacteremic melioidosis (ST-70 and ST-660) in 2 patients with prolonged neutropenia, who succumbed despite appropriate antibiotics. Clinicians should be aware of this emerging infection in neutropenic patients residing in or returning from(More)