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Fibrosis progression in nonalcoholic fatty liver vs nonalcoholic steatohepatitis: a systematic review and meta-analysis of paired-biopsy studies.
TLDR
Based on a meta-analysis of studies of paired liver biopsy studies, liver fibrosis progresses in patients with NAFL and NASH. Expand
Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: Systematic review and meta‐analysis
TLDR
The risk of liver‐related mortality increases exponentially with increase in fibrosis stage; these data have important implications in assessing the utility of each stage and benefits of regression of fibrosis from one stage to another. Expand
Association of Pharmacological Treatments for Obesity With Weight Loss and Adverse Events: A Systematic Review and Meta-analysis.
TLDR
All active agents were associated with significant excess weight loss compared with placebo at 1 year and phentermine-topiramate, naltrexone-bupropion, and liraglutide, each associated with 5% weight loss at 52 weeks, were linked with the highest odds of adverse event-related treatment discontinuation. Expand
Chemopreventive strategies in hepatocellular carcinoma
TLDR
Several commonly prescribed medications seem promising as chemopreventive agents against HCC, including statins, antidiabetic medications and aspirin, and dietary agents such as coffee, vitamin E and fish oil as well as phytochemicals might be associated with reduced risk of HCC. Expand
Statins are associated with a reduced risk of hepatocellular cancer: a systematic review and meta-analysis.
TLDR
Based on meta-analysis, statin use is associated with a reduced risk of HCC, most strongly in Asian but also in Western populations, and Randomized clinical trials in populations at high risk for HCC are warranted. Expand
Diagnostic performance of magnetic resonance elastography in staging liver fibrosis: a systematic review and meta-analysis of individual participant data.
TLDR
Based on a pooled analysis of data from individual participants, MRE has a high accuracy for the diagnosis of significant or advanced fibrosis and cirrhosis, independent of BMI and etiology of CLD. Expand
Liver stiffness is associated with risk of decompensation, liver cancer, and death in patients with chronic liver diseases: a systematic review and meta-analysis.
TLDR
Based on a meta-analysis of cohort studies, the degree of liver stiffness is associated with risk of decompensated cirrhosis, HCC, and death in patients with CLDs and might be used in risk stratification. Expand
American Gastroenterological Association Institute Guideline on Therapeutic Drug Monitoring in Inflammatory Bowel Disease.
TLDR
Therapeutic Drug Monitoring in Inflammatory Bowel Disease: Clinical Guidelines Committee concludes that the current literature on therapeutic drug monitoring is inadequate and calls for further research into this topic. Expand
Primary sclerosing cholangitis: diagnosis, prognosis, and management.
TLDR
Liver transplantation is the only available treatment for patients with advanced PSC, with excellent outcomes in this population, and cancer is the leading cause of mortality in patients with PSC. Expand
Antiviral therapy for chronic hepatitis B viral infection in adults: A systematic review and meta‐analysis
TLDR
Most of the current literature focuses on the immune active phases of chronic HBV infection; decision‐making in other commonly encountered and challenging clinical settings depends on indirect evidence. Expand
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