Siddharth Kamath

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A major question for gene therapy in brain concerns methods to administer therapeutic genes in a uniform manner over major portions of the brain. A second question in neuroimmunology concerns the extent to which monocytes migrate to the CNS in degenerative disorders. Here we show that CD11b+ cells (largely monocytes) isolated from the bone marrow of GFP(More)
A population of cells derived from human and rodent bone marrow has been shown by several groups of investigators to give rise to glia and neuron-like cells. Here we show that human umbilical cord blood cells treated with retinoic acid (RA) and nerve growth factor (NGF) exhibited a change in phenotype and expressed molecular markers usually associated with(More)
Bone marrow stromal cells (BMSC) have been shown to generate neural cells under experimental conditions in vitro and following transplantation into animal models of stroke and traumatic CNS injury. Hastened recovery from the neurological deficit has not correlated with structural repair of the lesion in the stroke model. Secretory functions of BMSC, such as(More)
The adipocyte-derived hormone leptin is crucial for energy homeostasis in mammals; mice and humans without it suffer from a voracious appetite and extreme obesity. The effect on energy balance of variations in plasma leptin above a minimal threshold is uncertain, however, particularly in humans. Here we examine a group of individuals who are genetically(More)
The prevailing vascular fluid dynamics plays an important role in the development of atheroscle-rosis which is one of the most wide spread disease in humans. The recent advances in computational fluid dynamics (CFD) can be useful in observing the flow behavior downstream of the stenosis. The present study investigates a simple case of 66% eccentric stenosis(More)
Elderly persons are more susceptible to RSV-induced pneumonia than young people, but the molecular mechanism underlying this susceptibility is not well understood. In this study, we used an aged mouse model of RSV-induced pneumonia to examine how aging alters the lung pathology, modulates antiviral gene expressions, and the production of inflammatory(More)
We propose a load balanced and energy aware routing protocol (LEAR) that is designed to improve the lifetime of large-scale wireless sensor mesh networks by balancing the energy consumption in the nodes. The proposed protocol selects routes to enable equitable traffic distribution across the nodes so that all nodes maintain similar expected lifetimes. We(More)
Gravity associated with postural changes has a strong bearing on haemodynamics of blood flow in arteries. Its effect on stenosed cases has not been widely investigated. In the present study, variation observed in blood flow during postural changes is investigated for different conditions like standing, sleeping and head-down position. A fluid structure(More)
Fluid-Structure Interaction (FSI) is one of the growing challenges in scientific computing wherein both fluid and structural solution domains are coupled using CFD and FEM methods respectively. Results from both the analysis are exchanged at interface junction in a synchronized manner to obtain an FSI solution. This study is helpful in observing the(More)
Computational Fluid Dynamics (CFD) is one of the growing challenges in scientific computing wherein the complex fluid domains are analyzed. One such domain is blood flow analysis through elastic arteries. Such an analysis can be a promising future for the medical field where realistic physiological conditions can be simulated to observe the flow behavior.(More)