Sid Bourke

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Purinergic excitatory synapses use ATP to mediate fast synaptic transmission via activation of P2X receptor cation channels, and this response can be altered by acute hypoxia. This study examined the effect of acute hypoxia on cloned homo- and heteromeric P2X2 and P2X3 receptors expressed in human embryonic kidney 293 cells. In cells expressing homomeric(More)
BACKGROUND Chronic ill-health may significantly impact on an individual's ability to work. This not only relates to disease severity but also to psychosocial factors such as illness perception and coping strategies. AIMS To explore the factors associated with employment status in adults with cystic fibrosis (CF). METHODS Subjects recruited from adult CF(More)
The late 20th Century saw the rapid rise of quality assurance in most industries and organisations, and in education quality assurance was epitomised as a concern with school effectiveness. Effectiveness measures most often took the form of standardised measures of student achievement in basic skills, and these measures remain the most salient today. While(More)
We find periodic I-band variability in two ultracool dwarfs, TVLM 513-46546 and 2MASS J00361617+1821104, on either side of the M/L dwarf boundary. Both of these targets are short-period radio transients, with the detected I-band periods matching those found at radio wavelengths (P=1.96 hr for TVLM 513-46546, and P=3 hr for 2MASS J00361617+1821104). We(More)
Aurorae are detected from all the magnetized planets in our Solar System, including Earth. They are powered by magnetospheric current systems that lead to the precipitation of energetic electrons into the high-latitude regions of the upper atmosphere. In the case of the gas-giant planets, these aurorae include highly polarized radio emission at kilohertz(More)
The class of type Ic supernovae have drawn increasing attention since 1998 owing to their sparse association (only four so far) with long duration gamma-ray bursts (GRBs). Although both phenomena originate from the core collapse of a massive star, supernovae emit mostly at optical wavelengths, whereas GRBs emit mostly in soft gamma-rays or hard X-rays.(More)
to the precipitation of energetic electrons into the high-latitude regions of the upper atmosphere. In the case of the gas giant planets, these aurorae include highly polarized radio emission at kHz and MHz frequencies produced by the precipitating electrons 2 , and a myriad of continuum and line emission in the infrared, optical, ultraviolet and X-rays(More)
Hyaluronan, a joint lubricant and regulator of synovial fluid content, is secreted by fibroblast-like synoviocytes lining the joint cavity, and secretion is greatly stimulated by Ca(2+)-dependent protein kinase C. This study aimed to define synoviocyte membrane currents and channels that may influence synoviocyte Ca(2+) dynamics. Resting membrane potential(More)
The relationship between obstetrician attitudes and patient outcomes from intrapartum care was examined. Obstetrician attitudes were assessed utilizing a newly-designed pilot 35-item obstetrician attitude questionnaire (OAQ). Twelve obstetricians completed the OAQ, who provided intra-partum care to 4,149 women. Outcome measures included delivery mode and(More)
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