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Dimensionality reduction is usually involved in the domains of artificial intelligence and machine learning. Linear projection of features is of particular interest for dimensionality reduction since it is simple to calculate and analytically analyze. In this paper, we propose an essentially linear projection technique, called locality-preserved maximum(More)
Traditional Chinese Herbal Medicine (TCHM) contain multiple botanicals, each of which contains many compounds that may be relevant to the medicine's putative activity. Therefore, analytical techniques that look at a suite of compounds, including their respective ratios, provide a more rational approach to the authentication and quality assessment of TCHM.(More)
The purpose of this study was to synthesize and characterize biodegradable and thermosensitive triblock copolymers for delivering protein at controlled rate in biologically active form for longer duration of time. A series of thermosensitive triblock copolymers with different block lengths (PLGA-PEG-PLGA) were synthesized by ring-opening polymerization of(More)
We first investigated the cytotoxicity of three cycloartane triterpenoids isolated from the aerial part of C. dahurica. Their cytotoxic activity was investigated on several cancer cell lines including solid tumor (HepG2), blood tumor (HL-60), drug resistant tumor (R-HepG2) and primary cultured normal mouse and rat hepatocytes in order to find efficient(More)
Synthetic chemical drugs, while being efficacious in the clinical management of many diseases, are often associated with undesirable side effects in patients. It is now clear that the need of therapeutic intervention in many clinical conditions cannot be satisfactorily met by synthetic chemical drugs. Since the research and development of new chemical drugs(More)
The objective of this research is to develop injectable controlled delivery systems for the contraceptive hormone, levonorgestrel (LNG), using phase sensitive and thermosensitive polymers. A combination of poly (lactide) (PLA) and a solvent mixture of benzyl benzoate (BB) and benzyl alcohol (BA) was used in the phase-sensitive polymer delivery systems. The(More)
The objective of this research is to develop injectable polymers solution based controlled release delivery systems for testosterone (TSN), using phase sensitive and thermosensitive polymers. A combination of poly(lactide) (PLA) and solvents mixture of benzyl benzoate (BB) and benzyl alcohol (BA) was used in the phase sensitive polymer delivery system. The(More)
Chromatographic fingerprinting has been widely accepted as a crucial method for qualitative and quantitative analyses of bioactives within traditional Chinese medicine. A fingerprint provides detailed information, specific for any given herb, thus facilitating the quality control measures of a given traditional Chinese medicine. In this article, quality(More)
In this paper, we propose a new approach, called local and weighted maximum margin discriminant analysis (LWMMDA), to performing object discrimination. LWMMDA is a subspace learning method that identifies the underlying nonlinear manifold for discrimination. The goal of LWMMDA is to seek a transformation such that data points of different classes are(More)