Learn More
BACKGROUND This is an update of a Cochrane review first published in The Cochrane Library in Issue 3, 2010.For many patients with head and neck cancer, oral nutrition will not provide adequate nourishment during treatment with radiotherapy or chemoradiotherapy due to the acute toxicity of treatment, obstruction caused by the tumour, or both. The optimal(More)
1. Repetitive firing in space-clamped squid axons bathed in low Ca and stimulated by a just suprathreshold step of current can be annihilated by a brief depolarizing or hyperpolarizing pulse of the proper magnitude applied at the proper phase. 2. In response to such perturbations, membrane potential and ionic currents show damped oscillations toward a(More)
that are known to play a part in the engulfment and removal of cell debris following brain injury. Although their function in the uninjured brain is unknown, new data suggests that they might have an important role in synapse elimination and pruning during development — a crucial stage of circuit formation. To visualize microglia and synapses in the mouse(More)
EMG and bandlimited noise (BLN) signals of comparable spectra were processed to compute the centroid and median frequencies and the high/low ratio for different record lengths, signal amplitudes, and noise bandwidths. The spectral moments of EMG and BLN showed similar statistical properties, independent of record length and amplitude. The signal-to-noise(More)
OBJECTIVE To examine whether age-related increase in concentrations of circulating inflammatory mediators is due to concurrent increases in cardiovascular risk factors or is independent of these. METHODS AND RESULTS Cytokines (IL-6, IL-18), chemokines (6Ckine, MCP-1, IP-10), soluble adhesion molecules (sICAM-1, sVCAM-1, sE-selectin) and adipokines(More)
Papillon-Lefevre syndrome (PLS) is an autosomal recessive disorder characterised by severe early onset periodontitis and palmoplantar hyperkeratosis. A previously reported missense mutation in the CTSC gene (NM_001814.4:c.899G>A:p.(G300D)) was identified in a homozygous state in two siblings diagnosed with PLS in a consanguineous family of Arabic ancestry.(More)
NATURE REVIEWS | NEUROSCIENCE VOLUME 12 | MAY 2011 A mutation in the gene encoding the postsynaptic density (PSD) protein SH3 and multiple ankyrin repeat domains protein 3 (SHANK3) has been identified by genetic screens as a candidate for autism spectrum disorders (ASDs), and is thought to be a crucial determinant of the behavioural deficits in the ASD(More)
and provide trophic support, which is essential for long-term maintenance of the axon and oligodendrocyte as a functional unit. The mechanisms by which this is achieved are not known, but Frühbeis, Fröhlich et al. now demonstrate that oligodendrocytederived exosomes (cargo-containing microvesicles) are important for this process. Oligodendrocytes are(More)