Siamak Salavatian

Learn More
  The aims of the study were to determine how aggregates of intrinsic cardiac (IC) neurons transduce the cardiovascular milieu versus responding to changes in central neuronal drive and to determine IC network interactions subsequent to induced neural imbalances in the genesis of atrial fibrillation (AF). Activity from multiple IC neurons in the right(More)
In this paper, we try to develop and implement the HRV signal processing into a Field Programmable Gate Array (FPGA) for extracting this signals feature. The hardware implementing algorithm was developed in Verilog Hardware Description Language (HDL). In designed hardware, after defining the number of samples in the input, it extracts and analyses the time(More)
In this paper, we try to recognize and distinguish different groups of arrhythmia using novel features which have been obtained from the heart rate's phase space in recent years. For this purpose, we used Triangular Phase Space Mapping (TPSM) and Parabolic Phase Space Mapping (PPSM). For recognition, we used three groups of 15 subjects using the Physionet(More)
BACKGROUND Autonomic regulation therapy involving either vagus nerve stimulation (VNS) or spinal cord stimulation (SCS) represents emerging bioelectronic therapies for heart disease. The objective of this study was to determine if VNS and/or SCS modulate primary cardiac afferent sensory transduction of the ischemic myocardium. METHODS Using extracellular(More)
Recent multielectrode array recordings in ganglionated plexi of canine atria have opened the way to the study of population dynamics of intrinsic cardiac neurons. These data provide critical insights into the role of local processing that these ganglia play in the regulation of cardiac function. Low firing rates, marked non-stationarity, interplay with the(More)
BACKGROUND Variability in premature ventricular contraction (PVC) coupling interval (CI) increases the risk of cardiomyopathy and sudden death. The autonomic nervous system regulates cardiac electrical and mechanical indices, and its dysregulation plays an important role in cardiac disease pathogenesis. The impact of PVCs on the intrinsic cardiac nervous(More)
Premature ventricular contractions (PVCs) are common in clinical practice. In structurally normal hearts, despite being referred to as benign, PVCs may lead to cardiomyopathy or even to sudden cardiac death. Recent clinical studies have identified factors that predict worse outcomes in PVC patients. Particularly, patients with PVCs showing high coupling(More)
Myocardial infarction causes sympathetic activation and parasympathetic dysfunction, which increase risk of sudden death due to ventricular arrhythmias. Mechanisms underlying parasympathetic dysfunction are unclear. The aim of this study was to delineate consequences of myocardial infarction on parasympathetic myocardial neurotransmitter levels and the(More)
Recent multichannel electrode array technology has enabled the simultaneous recording of multiple cardiac neurons located in ganglia on a beating heart. These new bioelectric signals are contaminated by the electrical activity of the atrial muscle just underneath. These atrial waveforms may mask relevant neuronal activity. In this paper, we evaluate the(More)
Mediastinal nerve stimulation (MNS) reproducibly evokes atrial fibrillation (AF) by excessive and heterogeneous activation of intrinsic cardiac (IC) neurons. This study evaluated whether preemptive vagus nerve stimulation (VNS) impacts MNS-induced evoked changes in IC neural network activity to thereby alter susceptibility to AF. IC neuronal activity in the(More)
  • 1