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The complexity, scale and dynamic of data source in the human-centric computing bring great challenges to maintainers. It is problem to be solved that how to reduce manual intervention in large scale human-centric computing, such as cloud computing resource management so that system can automatically manage according to configuration strategies. To address(More)
Computational drug repositioning or repurposing is a promising and efficient tool for discovering new uses from existing drugs and holds the great potential for precision medicine in the age of big data. The explosive growth of large-scale genomic and phenotypic data, as well as data of small molecular compounds with granted regulatory approval, is enabling(More)
Synergistic interactions among transcription factors (TFs) and their cofactors collectively determine gene expression in complex biological systems. In this work, we develop a novel graphical model, called Active Protein-Gene (APG) network model, to quantify regulatory signals of transcription in complex biomolecular networks through integrating both TF(More)
In extreme scale data processing systems, fault tolerance is an essential and indispensable part. Proactive fault tolerance scheme (such as the speculative execution in MapReduce framework) is introduced to dramatically improve the response time of job executions when the failure becomes a norm rather than an exception. Efficient proactive fault tolerance(More)
In the paper, a new kind of adaptive neural network control approach for a class of stochastic nonlinear system which in the form of non-strict-feedback is presented. Some difficulties, which occurred in the course of designing due to the non-strict-feedback structure, is overcomed by using the variable separation approach. A new kind of adaptive neural(More)
This paper presents a novel voltage stability sensitivity index incorporating the slip of wind generator and stochastic wind speed and load. Tradition studies are insufficient to inquire the impact of the slip of asynchronous wind generators and stochastic wind speed and load on voltage stability index. Firstly, the slip of asynchronous generator is(More)
Osmunda japonica Thunb., a medicinal plant newly recorded in the Chinese pharmacopoeia, has been used for centuries for treatment of viral influenza, dysentery, and bleeding. Although O. japonica and its adulterants have different medicinal effects and clinical applications, it is difficult to differentiate O. japonica from its adulterants used in medicine.(More)
Misconfigurations have drawn tremendous attention for their increasing prevalence and severity, and the main causes are the complexity of configurations as well as the lack of domain knowledge for software. To diagnose misconfigurations, one typical approach is to find out the conditions that configuration options should satisfy, which we refer to as(More)