Si Zheng

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Computational drug repositioning or repurposing is a promising and efficient tool for discovering new uses from existing drugs and holds the great potential for precision medicine in the age of big data. The explosive growth of large-scale genomic and phenotypic data, as well as data of small molecular compounds with granted regulatory approval, is enabling(More)
Synergistic interactions among transcription factors (TFs) and their cofactors collectively determine gene expression in complex biological systems. In this work, we develop a novel graphical model, called Active Protein-Gene (APG) network model, to quantify regulatory signals of transcription in complex biomolecular networks through integrating both TF(More)
In extreme scale data processing systems, fault tolerance is an essential and indispensable part. Proactive fault tolerance scheme (such as the speculative execution in MapReduce framework) is introduced to dramatically improve the response time of job executions when the failure becomes a norm rather than an exception. Efficient proactive fault tolerance(More)
Fault-tolerance is essential in extreme-scale data processing systems. Pro-active fault-tolerance scheme (such as the speculative execution in MapReduce framework), can dramatically improve the response time of job executions when the failure becomes norm rather than an exception. Efficient pro-active fault-tolerance schemes require precise knowledge on the(More)
In the age of big data, MapReduce plays an important role in the extreme-scale data processing system. Among all the hot issues, the data skew weights heavily for the MapReduce system performance. In traditional approaches, researchers attempt to leave the users to address the issue which requires the user to possess the application-dependent domain(More)
Osmunda japonica Thunb., a medicinal plant newly recorded in the Chinese pharmacopoeia, has been used for centuries for treatment of viral influenza, dysentery, and bleeding. Although O. japonica and its adulterants have different medicinal effects and clinical applications, it is difficult to differentiate O. japonica from its adulterants used in medicine.(More)
This paper presents a novel voltage stability sensitivity index incorporating the slip of wind generator and stochastic wind speed and load. Tradition studies are insufficient to inquire the impact of the slip of asynchronous wind generators and stochastic wind speed and load on voltage stability index. Firstly, the slip of asynchronous generator is(More)
Misconfigurations have drawn tremendous attention for their increasing prevalence and severity, and the main causes are the complexity of configurations as well as the lack of domain knowledge for software. To diagnose misconfigurations, one typical approach is to find out the conditions that configuration options should satisfy, which we refer to as(More)
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