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Recent data suggest that microaerophilic and parasitic protozoa, which lack oxidative phosphorylation, nevertheless contain mitochondrial homologs [1-6], organelles that share common ancestry with mitochondria. Such widespread retention suggests there may be a common function for mitochondrial homologs that makes them essential for eukaryotic cells. We(More)
BACKGROUND Iron-sulfur (FeS) proteins are present in all living organisms and play important roles in electron transport and metalloenzyme catalysis. The maturation of FeS proteins in eukaryotes is an essential function of mitochondria, but little is known about this process in amitochondriate eukaryotes. Here we report on the identification and analysis of(More)
BACKGROUND Giardia intestinalis is a parasitic protozoan and major cause of diarrhoeal disease. Disease transmission is dependent on the ability of the parasite to differentiate back and forth between an intestine-colonising trophozoite and an environmentally-resistant infective cyst. Our current understanding of the intracellular signalling mechanisms that(More)
The C4.5 decision tree and naive Bayes learners are known to produce unreliable probability forecasts. We have used simple binning (Zadrozny and Elkan, 2001) and Laplace transform (Cestnik, 2001) techniques to improve the reliability of these learners and compare their effectiveness with that of the newly developed Venn probability machine (VPM)(More)
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