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A new protein containing an SH2 domain that inhibits JAK kinases
The proliferation and differentiation of cells of many lineages are regulated by secreted proteins known as cytokines. Cytokines exert their biological effect through binding to cell-surface… Expand
Cloning and characterization of novel CIS family genes.
- M. Masuhara, H. Sakamoto, +10 authors A. Yoshimura
- Biology, Medicine
- Biochemical and biophysical research…
- 20 October 1997
We have reported two JAK-signaling modulators, CIS (cytokine-inducible SH2 protein) and JAB (JAK2 binding protein), which are structurally related. Here we cloned three additional CIS family genes… Expand
A Janus kinase inhibitor, JAB, is an interferon-gamma-inducible gene and confers resistance to interferons.
It has been shown that interferons (IFNs) exert their signals through receptor-associated Janus kinases (JAKs) and signal transducers and activators of transcription (STATs). However, molecular… Expand
Confers Resistance to Interferons Inducible Gene and − γ Kinase Inhibitor , JAB , Is an Interferon-Janus A
http://bloodjournal.hematologylibrary.org/content/92/5/1668.full.html Updated information and services can be found at: (4939 articles) Immunobiology Articles on similar topics can be found in the… Expand