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  • Jinzhi Tan, Shyla George, +9 authors Rolf Hilgenfeld
  • Biology, Medicine
  • Journal of virology
  • 2013 (First Published: 15 April 2013)
  • We have determined the cleavage specificity and the crystal structure of the 3C protease of enterovirus 68 (EV68 3C(pro)). The protease exhibits a typical chymotrypsin fold with a Cys...His...GluContinue Reading
  • Lili Zhu, Shyla George, Marco Schmidt, Samer I Al-Gharabli, Jörg Rademann, Rolf Hilgenfeld
  • Chemistry, Medicine
  • Antiviral research
  • 2011 (First Published: 1 November 2011)
  • SARS coronavirus main protease (SARS-CoV M(pro)) is essential for the replication of the virus and regarded as a major antiviral drug target. The enzyme is a cysteine protease, with a catalytic dyadContinue Reading
  • Laetitia Barbotte, Abdelhakim Ahmed-Belkacem, +11 authors J. M. Pawlotsky
  • Medicine, Biology
  • Antimicrobial agents and chemotherapy
  • 2010 (First Published: 1 June 2010)
  • We characterized a novel substitution conferring moderate resistance to telaprevir, a peptidomimetic inhibitor of hepatitis C virus protease. V36C conferred a 4.0-fold increase in the telaprevir 50%Continue Reading
  • Shyla George, Srinivasarao V. Narina, Arumugam Sudalai
  • Chemistry
  • 2007 (First Published: 1 February 2007)
  • Abstract The NaIO 4 -mediated asymmetric bromohydroxylation of α,β-unsaturated carboxamides was achieved using lithium bromide as the bromine source under acidic conditions at rt to afford theContinue Reading
  • Céline Masoni Lacroix, Shyla George, Pieter Leyssen, Rolf Hilgenfeld, Johan Neyts
  • Biology, Medicine
  • Antimicrobial agents and chemotherapy
  • 2015 (First Published: 1 September 2015)
  • The novel enterovirus protease inhibitor (PI) SG85 effectively inhibits the in vitro replication of 14 rhinoviruses representative of species A and B (median 50% effective concentration, 0.04 μM). AContinue Reading