Shyam Krishan Joshi

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We generated vascular cell adhesion molecule (VCAM)-1 "knock-in" mice and Cre recombinase transgenic mice to delete the VCAM-1 gene (vcam-1) in whole mice, thereby overcoming the embryonic lethality seen with conventional vcam-1-deficient mice. vcam-1 knock-in mice expressed normal levels of VCAM-1 but showed loss of VCAM-1 on endothelial and hematopoietic(More)
kappa-opioid receptor agonists (kappa-ORAs) have been shown to modulate visceral nociception through an interaction with a peripheral, possibly novel, kappa-opioid-like receptor. We used in the present experiments an antisense strategy to further explore the hypothesis that kappa-ORA effects in the colon are produced at a site different from the cloned(More)
The goal of the present study was to determine whether the kappa-opioid receptor agonist (ORA) U50,488 attenuates behavioral and primary afferent nerve responses to noxious colorectal distension (CRD) by sodium channel blockade. We tested the analgesic kappa-ORA (+/-)-trans U50,488, its enantiomers (-)-trans (1S,2S)-U50,488 and non kappa-ORA (+)-trans(More)
We have previously reported that U50,488 [(trans-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide] enantiomers contribute to visceral antinociception by a nonopioid receptor-mediated blockade of sodium currents in colon sensory neurons. The present experiments were undertaken to examine the effect of arylacetamide kappa-opioid(More)
The ability of arylacetamide kappa-opioid receptor agonists (kappa-ORAs) to block sodium channels by a nonopioid mechanism has been previously documented. The present experiments were undertaken to test whether two enantiomers of the arylacetamide kappa-ORA (trans)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide (U50,488),(More)
— This paper present the analysis of load frequency control problem for interconnected power system using the PID controller. Any small sudden load change in any of the areas causes the fluctuation of the frequencies of each and every area and also there is fluctuation of power in tie line of interconnected power system. Frequency should remain nearly(More)
— The problem of economic load dispatch has been tested on a generating plant having Ten units of generators operating in parallel. What shall be the load allocations to individual units for given load demand on the plant? has been found. The allocation of load to each of the ten generators in a generating plant is such that the economic load dispatch is(More)
— HVDC power transmission is coming up with merits to replace the EHV-AC systems. The controller inverter operation can successfully regulate the power in HVDC link leading to fulfillment of power demand in A.C. networks caused by sudden rise in loading. Since overloading and unloading both lead to the departure of operating frequency below or above normal,(More)
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