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Response and resistance to BET bromodomain inhibitors in triple negative breast cancer
Triple-negative breast cancer (TNBC) is a heterogeneous and clinically aggressive disease for which there is no targeted therapy. BET bromodomain inhibitors, which have shown efficacy in severalExpand
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Phospho switch triggers Brd4 chromatin binding and activator recruitment for gene-specific targeting.
Bromodomain-containing protein 4 (Brd4) is an epigenetic reader and transcriptional regulator recently identified as a cancer therapeutic target for acute myeloid leukemia, multiple myeloma, andExpand
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The SUMO E3-ligase PIAS1 regulates the tumor suppressor PML and its oncogenic counterpart PML-RARA.
The ubiquitin-like SUMO proteins covalently modify protein substrates and regulate their functional properties. In a broad spectrum of cancers, the tumor suppressor PML undergoes ubiquitin-mediatedExpand
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Recruitment of TFIIH to the HIV LTR is a rate‐limiting step in the emergence of HIV from latency
Latently infected cells rapidly initiate HIV transcription after exposure to signals that induce NF‐κB. To investigate the role of TFIIH during HIV reactivation in vivo, we developed a population ofExpand
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Brd4 Is Displaced from HPV Replication Factories as They Expand and Amplify Viral DNA
Replication foci are generated by many viruses to concentrate and localize viral DNA synthesis to specific regions of the cell. Expression of the HPV16 E1 and E2 replication proteins in keratinocytesExpand
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Human papillomavirus (HPV) origin-binding protein associates with mitotic spindles to enable viral DNA partitioning
Human papillomaviruses (HPVs) establish long-term infections in patients. The mechanism for extrachromosomal HPV DNA persistence in cycling cells is unknown. We show that HPV origin-containingExpand
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Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration
Abstract Hypoxia-inducible factor 1 (HIF-1) is a master transcriptional regulator in response to hypoxia and its transcriptional activity is crucial for cancer cell mobility. Here we present evidenceExpand
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Kub5-Hera, the human Rtt103 homolog, plays dual functional roles in transcription termination and DNA repair
Functions of Kub5-Hera (In Greek Mythology Hera controlled Artemis) (K-H), the human homolog of the yeast transcription termination factor Rtt103, remain undefined. Here, we show that K-H hasExpand
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Acetylation of Conserved Lysines in Bovine Papillomavirus E2 by p300
ABSTRACT The p300, CBP, and pCAF lysine acetyltransferase (KAT) proteins have been reported to physically interact with bovine (BPV) and human (HPV) papillomavirus E2 proteins. While overexpressionExpand
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Crosstalk between sumoylation and acetylation regulates p53‐dependent chromatin transcription and DNA binding
Covalent modification by small ubiquitin‐related modifiers (SUMO) regulates p53 transcription activity through an undefined mechanism. Using reconstituted sumoylation components, we purifiedExpand
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