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AIM Helicobacter pylori infection, though common, leads to gastric cancer (GC) in less than 1% individuals, suggesting the role of host factors. We previously reported the role of(More)
OBJECTIVES:We aimed at evaluating the role of interleukin-1B (IL-1B) and IL-1RN polymorphisms, which may modulate the gastric mucosal expression of IL-1β, thus altering acid secretion, which(More)
BACKGROUND Intestinal metaplasia (IM), a precursor of gastric cancer (GC), may be amenable to non-invasive assessment. AIMS We evaluated the diagnostic utility of serum PG-I, PG-II, PG-I/PG-II(More)
BACKGROUND AND AIM The relationship between gastroesophageal reflux disease (GERD) and Helicobacter pylori is controversial. We evaluated endoscopic, 24-h gastric and esophageal acid profile among(More)
BACKGROUND Microsomal epoxide hydrolase, an important phase II xenobiotic enzyme, exhibits polymorphisms at exon 3 (Tyr113His [T/C]) and exon 4 (His139Arg [A/G]), which modulate enzyme activity; this(More)