Shweta Singh

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In sympathetic neurons, unlike most nonneuronal cells, growth factor withdrawal-induced apoptosis requires the development of competence in addition to cytochrome c release to activate caspases. Thus, although most nonneuronal cells die rapidly with cytosolic cytochrome c alone, sympathetic neurons are remarkably resistant unless they develop competence. We(More)
Several workers have extensively worked out the metal induced toxicity and have reported the toxic and carcinogenic effects of metals in human and animals. It is well known that these metals play a crucial role in facilitating normal biological functions of cells as well. One of the major mechanisms associated with heavy metal toxicity has been attributed(More)
BACKGROUND The large-scale production of G-protein coupled receptors (GPCRs) for functional and structural studies remains a challenge. Recent successes have been made in the expression of a range of GPCRs using Pichia pastoris as an expression host. P. pastoris has a number of advantages over other expression systems including ability to(More)
In spite of the prevalence of IT outsourcing, the outcome of IT outsourcing contracts have been less than stellar. However, despite industry reports about dissatisfaction with the performance of IT outsourcing initiatives, there is a lack of research examining the outcome of IT outsourcing contracts. Given the difficulties in selecting appropriate vendors(More)
Phage-encoded serine integrases mediate directionally regulated site-specific recombination between short attP and attB DNA sites without host factor requirements. These features make them attractive for genome engineering and synthetic genetics, although the basis for DNA site selection is poorly understood. Here we show that attP selection is determined(More)
BACKGROUND Police personnel in India are subjected to several distinct occupational stressors which impact their mental health and their work performance negatively. AIM The study aimed to explore various sources of stress among police personnel. METHOD In this study, 100 constables, 100 inspectors and 100 police officers of Uttar Pradesh, were(More)
G-protein coupled receptors (GPCRs) are the targets of over half of all prescribed drugs today. The UniProt database has records for about 800 proteins classified as GPCRs, but drugs have only been developed against 50 of these. Thus, there is huge potential in terms of the number of targets for new therapies to be designed. Several breakthroughs in GPCRs(More)
A cloud storage mechanism repressed a storage device design and cloud based protocols. Cloud storage architecture can be exposed design for remote method access through cloud storage device. Cloud storage is a centralized data distribution center meant for authorized clients, among them cloud data will share towards different clients as apiece their(More)