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Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4
BackgroundIncreasing evidence indicates that the interaction between the CXC chemokine receptor-4 (CXCR4) and its ligand CXCL12 is critical in the process of metastasis that accounts for more than… Expand
Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype
- S. Vali, R. Pallavi, S. Kapoor, U. Tatu
- Biology, Medicine
- Systems and Synthetic Biology
- 24 October 2009
Hsp90 is an ATP-dependent molecular chaperone that regulates key signaling proteins and thereby impacts cell growth and development. Chaperone cycle of Hsp90 is regulated by ATP binding and… Expand
In silico modeling predicts drug sensitivity of patient-derived cancer cells
BackgroundGlioblastoma (GBM) is an aggressive disease associated with poor survival. It is essential to account for the complexity of GBM biology to improve diagnostic and therapeutic strategies.… Expand
Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide
We recently reported a novel interaction between Bcl-2 and Rac1 and linked that to the ability of Bcl-2 to induce a pro-oxidant state in cancer cells. To gain further insight into the functional… Expand
A Novel and Personalized Method Using Simulation for Predicting Effective Therapeutics for Waldenströms Macroglobulinemia
Background: The concept of treatment personalization in cancer often means associating a drug with an actionable mutation. One limitation of this approach is that most tumors have multiple… Expand
Clinical translation pathway for identifying patient-specific drugs based on predictive simulation outcomes with ex vivo validation.
e19582 Background: The unique signature of a patient’s tumor implies that a one-size-fits-all treatment approach is suboptimal, thereby underscoring the need to rationally design therapies employing… Expand
Predicting GBM response to targeted therapeutics using simulation with ex vivo validations.
2041 Background: The unique signature of a patient’s tumor implies that a one-size-fits-all treatment approach will likely fail. This necessitates a rationally designed personalized therapeutic app...
Predictive Simulation Based Design and Validation Of Repurposed Novel Therapeutics With Multi-Target Mechanisms For Multiple Myeloma
Introduction Development of resistance to single agent therapy is a significant clinical obstacle in the treatment of multiple myeloma (MM). Genetic mutations and the bone marrow micro-environment… Expand
SURFACE ASSESSMENT AND RECONSTRUCTION OF THE EXTRA AND INTRA-OSSEOUS ARTERIAL SUPPLY OF THE TALUS AND NAVICULAR
The arterial supply of the talus has been extensively studied in the past but there is a paucity of information on the arterial supply to the navicular and a very limited understanding of the… Expand
Abstract 5215: Computer based “virtual tumor” simulation identifies novel use for existing drugs - implication for personalized cancer therapy.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Background: Genomic tumor profiling studies have demonstrated that most cancer cells embody a multitude of genomic… Expand