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Plumbagin inhibits invasion and migration of breast and gastric cancer cells by downregulating the expression of chemokine receptor CXCR4
BackgroundIncreasing evidence indicates that the interaction between the CXC chemokine receptor-4 (CXCR4) and its ligand CXCL12 is critical in the process of metastasis that accounts for more thanExpand
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Virtual prototyping study shows increased ATPase activity of Hsp90 to be the key determinant of cancer phenotype
Hsp90 is an ATP-dependent molecular chaperone that regulates key signaling proteins and thereby impacts cell growth and development. Chaperone cycle of Hsp90 is regulated by ATP binding andExpand
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In silico modeling predicts drug sensitivity of patient-derived cancer cells
BackgroundGlioblastoma (GBM) is an aggressive disease associated with poor survival. It is essential to account for the complexity of GBM biology to improve diagnostic and therapeutic strategies.Expand
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Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide
We recently reported a novel interaction between Bcl-2 and Rac1 and linked that to the ability of Bcl-2 to induce a pro-oxidant state in cancer cells. To gain further insight into the functionalExpand
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A Novel and Personalized Method Using Simulation for Predicting Effective Therapeutics for Waldenströms Macroglobulinemia
Background: The concept of treatment personalization in cancer often means associating a drug with an actionable mutation. One limitation of this approach is that most tumors have multipleExpand
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Clinical translation pathway for identifying patient-specific drugs based on predictive simulation outcomes with ex vivo validation.
e19582 Background: The unique signature of a patient’s tumor implies that a one-size-fits-all treatment approach is suboptimal, thereby underscoring the need to rationally design therapies employingExpand
Predicting GBM response to targeted therapeutics using simulation with ex vivo validations.
2041 Background: The unique signature of a patient’s tumor implies that a one-size-fits-all treatment approach will likely fail. This necessitates a rationally designed personalized therapeutic app...
Predictive Simulation Based Design and Validation Of Repurposed Novel Therapeutics With Multi-Target Mechanisms For Multiple Myeloma
Introduction Development of resistance to single agent therapy is a significant clinical obstacle in the treatment of multiple myeloma (MM). Genetic mutations and the bone marrow micro-environmentExpand
The arterial supply of the talus has been extensively studied in the past but there is a paucity of information on the arterial supply to the navicular and a very limited understanding of theExpand
Abstract 5215: Computer based “virtual tumor” simulation identifies novel use for existing drugs - implication for personalized cancer therapy.
Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC Background: Genomic tumor profiling studies have demonstrated that most cancer cells embody a multitude of genomicExpand