• Publications
  • Influence
Long term azithromycin therapy in cystic fibrosis patients: a study on drug levels and sputum properties.
BACKGROUND Following reports on the treatment of diffuse panbronchiolitis (DPB), recent studies demonstrate that long term therapy with azithromycin (AZM) is effective in cystic fibrosis (CF)Expand
  • 48
  • 2
  • Open Access
Thioredoxin liquefies and decreases the viscoelasticity of cystic fibrosis sputum.
The persistent and viscous nature of airway secretions in cystic fibrosis (CF) disease leads to airway obstruction, opportunistic infection, and deterioration of lung function. Thioredoxin (Trx) is aExpand
  • 27
  • 1
  • Open Access
Traditional Chinese medicinal herbs for the treatment of idiopathic chronic fatigue and chronic fatigue syndrome.
BACKGROUND Chronic fatigue is increasingly common. Conventional medical care is limited in treating chronic fatigue, leading some patients to use traditional Chinese medicine therapies, includingExpand
  • 40
  • 1
  • Open Access
Adaptation of an amphibian mucociliary clearance model to evaluate early effects of tobacco smoke exposure
RationaleInhaled side-stream tobacco smoke brings in all of its harmful components impairing mechanisms that protect the airways and lungs. Chronic respiratory health consequences are a complexExpand
  • 19
  • 1
  • Open Access
Additive effect of dornase alfa and Nacystelyn on transportability and viscoelasticity of cystic fibrosis sputum.
OBJECTIVE To investigate the effect of dornase alfa (DA), Nacystelyn (NAL) and their combination on mucociliary transportability and mucus viscoelasticity of cystic fibrosis (CF) sputum, and toExpand
  • 21
  • 1
  • Open Access
A mechanism of airway injury in an epithelial model of mucociliary clearance
We studied the action of sodium metabisulphite on mucociliary transport in a frog palate epithelial injury model, hypothesizing that it may be useful for the study of mechanisms of airway injury.Expand
  • 15
  • 1
Effect of needle puncture and electro-acupuncture on mucociliary clearance in anesthetized quails
BackgroundAcupuncture therapy for obstructive respiratory diseases has been effectively used in clinical practice and the acupuncture points or acupoints of Zhongfu and Tiantu are commonly-usedExpand
  • 9
  • 1
  • Open Access
Formulation and In Vivo Evaluation of Effervescent Inhalable Carrier Particles for Pulmonary Delivery of Nanoparticles
The purpose of this study was to evaluate the safety of a new inhalable effervescent carrier preparation containing model nanoparticles. Spray-freeze drying was used to prepare inhalable powdersExpand
  • 27
Evaluation of a Mucoactive Herbal Drug, Radix Ophiopogonis, in a Pathogenic Quail Model
We investigated the effect of Radix Ophiopogonis on airway mucociliary clearance and mucus secretion in anesthetized quails. The oral administration of 10 g/kg of Radix Ophiopogonis significantlyExpand
  • 7