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Quantitative structure-activity relationship (QSAR) analysis has become one of the most effective approaches for optimizing lead compounds and designing new drugs. Although large number of quantum-chemical descriptors were defined and applied successfully, it is still a big challenge to develop a general quantum-chemical descriptor describing the bulk(More)
The T2K off-axis near detector, ND280, is used to make the first differential cross section measurements of muon neutrino charged current single positive pion production on a water target at energies ∼0.8 GeV. The differential measurements are presented as a function of the muon and 3 pion kinematics, in the restricted phase-space defined by p π + > 200(More)
GPR35, an orphan G protein-coupled receptor, has attracted much attention as a novel therapeutic target for the treatment of diabetes, hypertension, etc. Recently, 8-substituted chromen-4-one-2-carboxylic acid derivatives were identified as potent and selective agonists for human GPR35. In the present study, the three-dimensional quantitative(More)
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