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Potent cytotoxicity of the phosphatase inhibitor microcystin LR and microcystin analogues in OATP1B1- and OATP1B3-expressing HeLa cells
TLDR
These studies show that microcystin-induced phosphatase inhibition results in potent cytotoxicity when micro Cystin compounds can gain intracellular access and are a potent novel class of therapeutic agents for tumors expressing these uptake proteins.
Roles of Rad23 protein in yeast nucleotide excision repair.
TLDR
The results support two roles of Rad23 protein in NER: its direct participation in the repair biochemistry, possibly due to its stimulatory activity on Rad4-mediated damage binding/recognition; and its stabilization of cellular Rad4 protein.
NAD+-linked 15-hydroxyprostaglandin dehydrogenase (15-PGDH) behaves as a tumor suppressor in lung cancer.
TLDR
RNA levels of the key prostaglandin catabolic enzyme, NAD+-linked 15-hydroxyprostagland in dehydrogenase (15-PGDH), are analyzed and it is suggested that 15-PG DH may decrease the level of proliferative PGE2, induce apoptosis and function like a tumor suppressor.
Down-regulation of thiamine transporter THTR2 gene expression in breast cancer and its association with resistance to apoptosis.
TLDR
Thiamine transporter THTR2 gene expression is down-regulated in breast cancer, which may contribute to resistance to apoptosis in these tumors.
Thiamine transporter gene expression and exogenous thiamine modulate the expression of genes involved in drug and prostaglandin metabolism in breast cancer cells.
TLDR
Three studies show unexpected relationships between thiamine metabolism and genes that may be involved in the oncogenesis of breast and lung cancer.
Specific association of thiamine-coated gadolinium nanoparticles with human breast cancer cells expressing thiamine transporters.
TLDR
Thiamine-coated nanoparticle association with THTR1 and THTR2 cells was significantly greater than that with control breast cancer cells (MTX(R)ZR75 transfected with the empty expression vector pREP4) (p < 0.01; t-test).
Sensitivity of breast cancer cell lines to recombinant thiaminase I
TLDR
Thiaminase I is cytotoxic in breast cancer cell lines and triggers the unfolded protein response, suggesting that THTR2 down-regulation in breast tumors may present a nutritional vulnerability that could be exploited by thiamin enzyme I enzyme therapy.
Recombinant Domain V of β2-Glycoprotein I Inhibits the Formation of Atherogenic oxLDL/β2-Glycoprotein I Complexes
TLDR
The present work provides a new effective strategy to prevent the progression of atherothrombotic vascular complications in APS patients by inhibiting the formation of oxLDL/β2-GPI complexes, a potential approach for reducing foam cell development and mitigating atherogenesis in patients with APS.
Metabolic Effects of Acute Thiamine Depletion Are Reversed by Rapamycin in Breast and Leukemia Cells
TLDR
It is demonstrated that acute intracellular thiamine depletion by recombinant thiaminase results in metabolic changes inThiamine-dependent metabolism, and demonstrate a previously unrecognized role of mTOR signaling in the regulation of thiamined metabolism.
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