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BACKGROUND The morphological changes of the retinal blood vessels in retinal images are important indicators for diseases like diabetes, hypertension and glaucoma. Thus the accurate segmentation of blood vessel is of diagnostic value. METHODS In this paper, we present a novel method to segment retinal blood vessels to overcome the variations in contrast(More)
The success of image analysis depends heavily upon accurate image segmentation algorithms. This paper presents a novel segmentation algorithm based on artificial ant colonies (AC). Recent studies show that the self-organization of ants is similar to neurons in the human brain in many respects. Therefore, it has been used successfully for understanding(More)
BACKGROUND Computed Tomography (CT) is a technology that obtains the tomogram of the observed objects. In real-world applications, especially the biomedical applications, lower radiation dose have been constantly pursued. To shorten scanning time and reduce radiation dose, one can decrease X-ray exposure time at each projection view or decrease the number(More)
The virtual human is an interactive computer model integrating anatomical, biophysical, physiological and biomechanical characteristics of human being. The virtual Chinese human female number 1 (VCH-F1) is a high-resolution dataset of a standard Chinese female. This paper covers our 5-year work with VCH-F1 dataset. We will introduce the reconstruction of(More)
BACKGROUND Early detection of lung cancer is known to improve the chances of successful treatment. However, lungs are soft tissues with complex three-dimensional configuration. Conventional X-ray imaging is based purely on absorption resulting in very low contrast when imaging soft tissues without contrast agents. It is difficult to obtain adequate(More)
The purpose of this paper is to report the noninvasive imaging of hepatic tumors without contrast agents. Both normal tissues and tumor tissues can be detected, and tumor tissues in different stages can be classified quantitatively. We implanted BEL-7402 human hepatocellular carcinoma cells into the livers of nude mice and then imaged the livers using X-ray(More)
The current imaging methods have a limited ability to visualize microstructures of biological soft tissues. Small lesions cannot be detected at the early stage of the disease. Phase contrast imaging (PCI) is a novel non-invasive imaging technique that can provide high contrast images of soft tissues by the use of X-ray phase shift. It is a new choice in(More)
BACKGROUND This paper is to report the new imaging of gastric cancers without the use of imaging agents. Both gastric normal regions and gastric cancer regions can be distinguished by using the principal component analysis (PCA) based on the gray level co-occurrence matrix (GLCM). METHODS Human gastric cancer BGC823 cells were implanted into the stomachs(More)
BACKGROUND The Filtered Back-Projection (FBP) algorithm is the most important technique for computerized tomographic (CT) imaging, in which the ramp filter plays a key role. FBP algorithm had been derived using the continuous system model. However, it has to be discretized in practical applications, which necessarily produces distortion in the reconstructed(More)
BACKGROUND [corrected] Hepatic fibrosis can lead to deformation of vessel morphology and structure. In the present feasibility study, high-resolution computed tomography (CT) using diffraction-enhanced imaging (DEI) was used to represent three-dimensional (3D) vessel microstructures of hepatic fibrosis in rats and to differentiate different stages of(More)