Shuoshuo Wang

  • Citations Per Year
Learn More
Contractile muscle fibers produce enormous intrinsic forces during contraction/relaxation waves. These forces are directly applied to their cytoplasmic organelles including mitochondria, sarcoplasmic reticulum, and multiple nuclei. Data from our analysis of Drosophila larval somatic muscle fibers suggest that an intricate network of organized microtubules(More)
Muscle nuclei are exposed to variable cytoplasmic strain produced by muscle contraction and relaxation, but their morphology remains stable. Still, the mechanism responsible for maintaining myonuclear architecture, and its importance, is currently elusive. Herein, we uncovered a unique myonuclear scaffold in Drosophila melanogaster larval muscles,(More)
Nuclear morphology and architecture are maintained by nucleoskeletal elements including, chromatin associated factors and nuclear lamina components both of which are involved in the regulation of chromatin 3D organization [1, 2]. As such, differentiated cells maintain a tissue-specific nuclear distribution of the euand heterochromatin and contain(More)
Alterations in nuclear shape and positioning are often associated with changes in the behavior of cells (Starr and Fridolfsson, 2010). Recent studies proposed that tissue stiffness affects the levels of the nuclear lamina protein lamin A/C, resulting in altered transcriptional regulation (Simon and Wilson, 2011; Burke and Stewart, 2013; Zwerger et al.,(More)
  • 1