Shuodan Chen

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OBJECTIVE To evaluate the effects of injurious compression on the biosynthesis of lubricin at different depths within articular cartilage and to examine alterations in structure and function of the articular surface following mechanical injury. METHODS Bovine cartilage explants were subdivided into level 1, with intact articular surface, and level 2,(More)
The dense extracellular matrix (ECM) within the articular cartilage derives its compressive modulus from the electrostatic and osmotic interactions between highly charged glycosaminoglycan (GAG) chains. Furthermore, the structural integrity of the ECM comes from the tightly interwoven collagen network, which accounts for the tensile and shear stiffness of(More)
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