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Nanopore stochastic detection: diversity, sensitivity, and beyond.
Nanopore sensors have emerged as a label-free and amplification-free technique for measuring single molecules. First proposed in the mid-1990s, nanopore detection takes advantage of the ionic currentExpand
Structure-based virtual screening leading to discovery of highly selective butyrylcholinesterase inhibitors with solanaceous alkaloid scaffolds.
According to recent research advance, it is interesting to identify new, potent and selective inhibitors of human butyrylcholinesterase (BChE) for therapeutic treatment of both the Alzheimer'sExpand
Discovery of potent and selective butyrylcholinesterase inhibitors through the use of pharmacophore-based screening.
Cholinesterase inhibitors have long been used in the treatment of Alzheimer's Disease (AD) via the protection of acetylcholine levels. However, recent research has shown that the specific inhibitionExpand
Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs
Human mPGES-1 is recognized as a promising target for next generation of anti-inflammatory drugs without the side effects of currently available anti-inflammatory drugs, and various inhibitors haveExpand
Real-time label-free measurement of HIV-1 protease activity by nanopore analysis.
A label-free method for the measurement of the activity of HIV-1 protease is developed by real-time monitoring of the cleavage of a peptide substrate by HIV-1 protease in a nanopore. The method isExpand
Nanopore detection of copper ions using a polyhistidine probe.
We report a stochastic nanopore sensing method for the detection of Cu(2+) ions. By employing a polyhistidine molecule as a chelating agent, and based on the different signatures of the eventsExpand
Nanopore Biosensor for Label-Free and Real-Time Detection of Anthrax Lethal Factor
We report a label-free real-time nanopore sensing method for the detection of anthrax lethal factor, a component of the anthrax toxin, by using a complementary single-stranded DNA as a molecularExpand
Label-free nanopore single-molecule measurement of trypsin activity.
Trypsin is the most important digestive enzyme produced in the pancreas, and is a useful biomarker for pancreatitis. In this work, a rapid and sensitive method for the quantitative determination ofExpand
Selective inhibitors of human mPGES-1 from structure-based computational screening.
Human mPGES-1 is recognized as a promising target for next generation of anti-inflammatory drugs. Although various mPGES-1 inhibitors have been reported in literature, few have entered clinicalExpand
Cell adhesion on supported lipid bilayers functionalized with RGD peptides monitored by using a quartz crystal microbalance with dissipation.
Supported lipid bilayer (SLB) is one of the most widely used structures to mimic cell membranes. To study the cell-cell, cell-matrix and cell-material interactions, supported lipid bilayers (SLBs)Expand