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  • Hiroyuki Tada, Eiji Nemoto, +10 authors Haruhiko Takada
  • Medicine, Biology
  • Microbiology and immunology
  • 2002 (First Publication: 1 July 2002)
  • The cytokine-inducing activities of fungal polysaccharides were examined in human monocytes in culture, with special reference to CD14 and Toll-like receptors (TLRs). Tumor necrosis factor alphaContinue Reading
  • Junko Hatakeyama, Riyoko Tamai, Akiko Sugiyama, Sachiko Akashi, Shunji Sugawara, Haruhiko Takada
  • Biology, Medicine
  • Oral microbiology and immunology
  • 2003 (First Publication: 1 February 2003)
  • We compared human periodontal ligament fibroblasts with human gingival fibroblasts isolated from the same donor to examine interleukin-8 (IL-8) responses of the cells to SalmonellaContinue Reading
  • Shunji Sugawara, Eiji Nemoto, Hiroyuki Tada, Katsuya Miyake, Takahisa Imamura, Haruhiko Takada
  • Biology, Medicine
  • The Journal of Immunology
  • 2000 (First Publication: 1 July 2000)
  • Cysteine proteinases (gingipains) elaborated from Porphyromonas gingivalis exhibit enzymatic activities against a broad range of host proteins and are considered key virulence factors in the onsetContinue Reading
  • Akiko Uehara, Shu-xu Yang, +5 authors Haruhiko Takada
  • Biology, Medicine
  • Cellular microbiology
  • 2005 (First Publication: 4 August 2004)
  • Two types of synthetic peptidoglycan fragments, diaminopimelic acid (DAP)-containing desmuramylpeptides (DMP) and muramyldipeptide (MDP), induced secretion of interleukin (IL)-8 in a dose-dependentContinue Reading
  • Azusa Sakai, Yumiko Sugawara, T Kuroishi, Takashi Sasano, Shunji Sugawara
  • Medicine, Biology
  • The Journal of Immunology
  • 2008 (First Publication: 15 August 2008)
  • IL-18 is a proinflammatory cytokine and plays an important pathogenic role in inflammatory and autoimmune disorders. IL-17 is also a proinflammatory cytokine and IL-17-secreting Th17 cells areContinue Reading
  • Shunji Sugawara, Toru Abo, Kotaro Kumagai
  • Biology, Medicine
  • Journal of immunological methods
  • 1987 (First Publication: 1 June 1987)
  • We describe here a simple, reproducible method which specifically eliminates the antigenicity of surface class I major histocompatibility complex (MHC) molecules by acid treatment at pH 3 from theContinue Reading
  • Akiko Uehara, Koji Muramoto, Haruhiko Takada, Shunji Sugawara
  • Medicine
  • The Journal of Immunology
  • 2003 (First Publication: 1 June 2003)
  • Protease-activated receptors (PARs) compose a family of G protein-coupled receptors activated by proteolysis with exposure of their tethered ligand. Recently, we reported that a neutrophil-derivedContinue Reading
  • Akiko Uehara, Shunji Sugawara, Haruhiko Takada
  • Medicine, Biology
  • Journal of medical microbiology
  • 2002 (First Publication: 1 August 2002)
  • An earlier study reported that human gingival epithelial cells in primary culture and oral epithelial cell lines KB and HSC-2 cells were devoid of membrane CD14 (mCD14) and did not show enhancedContinue Reading