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An MMP liberates the Ninjurin A ectodomain to signal a loss of cell adhesion.
TLDR
The identification of NijA, a transmembrane protein whose vertebrate homologs regulate cell adhesion, as a two-hybrid binding partner for Mmp1 is reported, suggesting that tracheal cellAdhesion is regulated by a novel mechanism utilizing an MMP and a ninjurin family member.
Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b
TLDR
Evidence is provided that the transcription factor Bcl11b/Ctip2 controls hallmark features of CD8+ T cell immunity, specifically antigen (Ag)-dependent clonal expansion and cytolytic activity.
Inhibition of p16INK4A to Rejuvenate Aging Human Cardiac Progenitor Cells via the Upregulation of Anti-oxidant and NFκB Signal Pathways
TLDR
The results suggest that genetic knockdown of p16INK4A may play a significant role in inducing antioxidant effects and extending lifespan of aging hCPCs and may enhance the effectiveness of autologous hC PC therapy for repair of infarcted myocardium.
Cytoglobin Promotes Cardiac Progenitor Cell Survival against Oxidative Stress via the Upregulation of the NFκB/iNOS Signal Pathway and Nitric Oxide Production
TLDR
A role for a globin in regulating hCPC survival and mechanistic insights in the function of CYGB are established, providing a rationale for the exploration of the CYGB pathway as a molecular target to enhance the effectiveness of cardiac stem/progenitor cell therapy for ischemic heart disease.
Neuraminidase 1 Exacerbating Aortic Dissection by Governing a Pro-Inflammatory Program in Macrophages
TLDR
It is demonstrated that macrophage-derived NEU1 is critical for vascular homeostasis and exacerbates BAPN-induced pathological vascular remodeling, and may represent a potential therapeutic target for the treatment of AD.
Abstract 337: Cytoglobin Promotes Cardiac Stem Cell Survival Against Oxidative Stress via the Upregulation of the NFkB/iNOS Signal Pathway and Nitric Oxide Production
TLDR
This study delineates for the first time a role for a globin in regulating hCSC survival and establishes novel mechanistic insights in the functional role of CYGB.
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