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Nicotine, a major alkaloid in tobacco plants and the main toxic chemical in tobacco wastes, can be transformed by bacteria into hydroxylated-pyridine intermediates, which are important precursors for the chemical synthesis of valuable drugs and insecticides. Such biotransformation could be a useful approach to utilize tobacco and its wastes. In this study,(More)
The problem of constructing a general continuous piecewise-linear neural network is considered in this paper. It is shown that every projection domain of an arbitrary continuous piecewise-linear function can be partitioned into convex polyhedra by using difference functions of its local linear functions. Based on these convex polyhedra, a group of(More)
BACKGROUND The enrichment and importance of some aromatic residues, such as Tyr and Trp, have been widely noticed at the binding interfaces of antibodies from many experimental and statistical results, some of which were even identified as "hot spots" contributing significantly greater to the binding affinity than other amino acids. However, how these(More)