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The severity of infections caused by Candida albicans, the most common opportunistic human fungal pathogen, needs rapid and effective antifungal treatments. One of the effective ways is to control the virulence factors of the pathogen. Therefore, the current study examined the effects of genistein, a natural isoflavone present in soybeans, on C. albicans.(More)
The pathogenic fungus Candida albicans is able to cover its most potent proinflammatory cell wall molecules, the β-glucans, underneath a dense mannan layer, so that the pathogen becomes partly invisible for immune cells such as phagocytes. As the C. albicans histidine kinases Chk1p, Cos1p and CaSln1p had been reported to be involved in virulence and cell(More)
Genistein is a well known natural compound which is present in soy foods and exerts many beneficial functions such as anticancer, anti-inflammatory and antioxidant. However, until now little is known about the effects of genistein on the function of macrophages. The murine macrophage cell line RAW264.7 was used as target cell line. The results show that at(More)
OBJECTIVE To investigate the role of spleen tyrosine kinase (Syk)on the Toll-like receptor 4 (TLR4) signal transduction cascade. METHODS RAW264.7 macrophages were treated with different concentrations of Syk inhibitor and then stimulated with 100 ng/mL lipopolysaccharide (LPS). The cell viability was tested by the Alarmarblue assay. The NO production was(More)
Genistein is one of the main components of soy-based foods, which are widely known for their many benefits, including anti-cancer, anti-inflammatory, and antioxidant effects. In this study, we investigated the anti-metastasis effects of genistein on B16F10 melanoma cells. Our results showed that genistein strongly inhibited B16F10 cell proliferation and(More)
OBJECTIVE To delineate and confirm the signaling processes involving mitogen-activated protein kinase (MAPK) and Toll-like receptor (TLR) in the regulation of lipopolysaccharide (LPS)-induced activity of macrophages by genistein at the protein and transcriptional levels. METHODS RAW264.7 macrophages were treated with genistein and then stimulated with LPS(More)
OBJECTIVE To investigate the anti-inflammatory effect of pretreatment with quercetin on macrophages after Candida albicans infection. METHODS RAW 264.7 macrophages were used as a target cell line. Cell viability after treatment with quercetin at different time points was detected by Carboxyfluorescein diacetate, succinimidyl ester. Phagocytic function of(More)
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