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Functional interleukin‐33 receptors are expressed in early progenitor stages of allergy‐related granulocytes
Interleukin‐33 (IL‐33) induces T helper type 2 (Th2) cytokine production and eosinophilia independently of acquired immunity, leading to innate immunity‐mediated allergic inflammation.… Expand
The association of airway comorbidities with the clinical phenotypes and outcomes of ANCA-associated vasculitis patients.
OBJECTIVE We investigated the association of airway comorbidities with the clinical phenotypes and outcomes of myeloperoxidase (MPO)-anti-neutrophil cytoplasmic antibodies (ANCA)-positive… Expand
Generation mechanism of RANKL+ effector memory B cells: relevance to the pathogenesis of rheumatoid arthritis
BackgroundThe efficacy of B cell-depleting therapies for rheumatoid arthritis underscores antibody-independent functions of effector B cells such as cognate T–B interactions and production of… Expand
Activation of central/effector memory T cells and T‐helper 1 polarization in malignant melanoma patients treated with anti‐programmed death‐1 antibody
Human anti‐programmed death‐1 (PD‐1) antibody possesses the capability to revitalize host T cells and has been an effective therapy for metastatic malignant melanoma (MM). The precise subsets of T… Expand
Clinicopathological significance of cervical adenocarcinoma associated with lobular endocervical glandular hyperplasia.
- S. Nishio, H. Tsuda, +6 authors O. Matsubara
- Medicine, Biology
- Pathology, research and practice
- 15 May 2009
Lobular endocervical glandular hyperplasia (LEGH) is usually assumed to be a benign tumor-like lesion of the glands of the uterine cervix. However, LEGH has been associated with obvious cervical… Expand
CIN85 is required for Cbl-mediated regulation of antigen receptor signaling in human B cells.
The aberrant regulation of B-cell receptor (BCR) signaling allows unwanted B cells to persist, thereby potentially leading to autoimmunity and B-cell malignancies. Casitas B-lineage lymphoma (Cbl)… Expand
AB0201 Cell Surface Expression of DNAM-1 (CD226) on CD8+ T Cells is Increased in Patients with Systemic Sclerosis
Background DNAM-1 (CD226) is well known as a genetic risk factor of many autoimmune diseases such as systemic sclerosis (SSc). More recently, Avouac et al. have reported that mice deficient for… Expand
Sophora Flavescens Suppresses Lung Eosinophilia By Inhibiting Both Eosinophil Hematopoiesis and Migration
Hirofumi Tsuzuki, Yojiro Arinobu, Kohta Miyawaki, Ayako Takaki, Shun-ichiro Ota, Naoko Ueki, Yuri Ota, Siamak Jabbarzadeh Tabrizi, Mitsuteru Akahoshi, Hiroaki Niiro, Hiroshi Tsukamoto, Takahiko… Expand
IL-33 Induces Cytokine Production By Lineage-Committed Myeloid Progenitors and Positively Regulates Eosinophil Hematopoiesis in IL-5-Dependent Manner