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The H2O2 generated by menadione kills cultured hepatocytes by a mechanism that depends in large part on a cellular source of ferric iron. Chelation of this iron by deferoxamine reduced by two-thirds the number of dead cells without any effect on the loss of 30% of total protein thiols, the formation of protein mixed disulfides, or the accumulation of(More)
The preparation of crystalline, ordered thin films of metal-organic frameworks (MOFs) will be a critical process for MOF-based nanodevices in the future. MOF thin films with perfect orientation and excellent crystallinity were formed with novel nanosheet-structured components, Cu-TCPP [TCPP = 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin], by a new "modular(More)
The electrical properties of a highly oriented crystalline MOF nanofilm were studied. This nanofilm has low activation energy and a proton conductivity that is among the highest value reported for MOF materials. The study uncovered the reasons for the excellent performance of this nanofilm and revealed a new pathway for proton transport in MOF materials;(More)
The fabrication of porous coordination frameworks in thin-film forms has been investigated intensively with a view to using their structural response to external stimuli and guests for potential nanotechnological applications, for example as membranes for gas separation. Here we report a coordination framework that exhibits a dynamic guest-sorption(More)
It was recently suggested that beta-adrenergic receptor binding in the rat brain was decreased by repeated electric shocks. In order to examine whether this phenomenon is observed under another stressor, the activity-stress paradigm was used in the present study. Rats were divided into 3 groups of AS, DC and AC.AS was housed in a cage with a running wheel(More)
In view of the fact that antidepressant drugs have almost no effect on a normal person's emotion and behavior, it seems necessary to examine their effects on animal behavior under abnormal, or stressful conditions. When mice were put into a water wheel apparatus, they tried to escape from the water by turning the wheel. This "wheel-turning behavior" was(More)
We report the fabrication and characterization of the first example of a tetracyanonickelate-based two-dimensional-layered metal-organic framework, {Fe(py)2Ni(CN)4} (py = pyridine), thin film. To fabricate a nanometer-sized thin film, we utilized the layer-by-layer method, whereby a substrate was alternately soaked in solutions of the structural components.(More)
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