Shun-Ichi Nakamura

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Transforming growth factor b (TGF-b) contributes to the progression of pulmonary fibrosis through up-regulation of a–smooth muscle actin (a–SMA) as lung myofibroblast differentiation. Bio-active sphingosine 1-phosphate (S1P) has been shown to mimic TGF-b signals; however, the function of S1P in lung fibrotic process has not been well documented. We found,(More)
To understand the expression of NADPH oxidase components during neutrophil maturation, we examined the expression of mRNAs and proteins for NADPH oxidase components, and the superoxide-producing activity using HL-60 cells incubated with dimethyl sulfoxide (DMSO). Northern blot and Western blot analyses revealed that gp91(phox), p67(phox), and p47(phox) were(More)
Transforming growth factor β (TGFβ) contributes to the progression of pulmonary fibrosis through up-regulation of α-smooth muscle actin (αSMA) as lung myofibroblasts differentiation. Bioactive sphingosine 1-phosphate (S1P) has been shown to mimic TGFβ signals, however the function of S1P in lung fibrotic process has not been well documented. We found, in(More)
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