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A set of 142 winter wheat recombinant inbred lines (RILs) deriving from the cross Heshangmai × Yu8679 were tried in four ecological environments during the seasons 2006 and 2007. Nine agronomic traits comprising mean grain filling rate (GFRmean), maximum grain filling rate (GFRmax), grain filling duration (GFD), grain number per ear (GNE), grain weight per(More)
Secondary organic carbon (SOC) formation and its effects on human health require better understanding in Chinese megacities characterized by a severe particulate 362 pollution and robust economic reform. This study investigated organic carbon (OC) and elemental carbon (EC) in PM2.5 and PM0.25 collected 8–20 March 2012. Samples were collected inside and(More)
Understanding the underlying properties-dependent interactions of nanostructures with biological systems is essential to nanotoxicological research. This study investigates the relationship between particle size and toxicity, and further reveals the mechanism of injury, using silica particles (SP) with diameters of 30, 70, and 300 nm (SP30, SP70, and SP300)(More)
Three doses of (+)-usnic acid (100, 200, and 240 mg/kg per d) were administered orally to Wistar rats for 8 days, and metabonomic characterization of (+)-usnic acid-induced liver injury based on gas chromatography-mass spectrometry metabolic profiles was evaluated. Serum biochemical analysis and histopathological examinations were simultaneously performed.(More)
Along with an indispensable role in healthcare system of China for centuries, Traditional Chinese Medicine (TCM) shows increasing usages as complementary therapy in western countries. To improve our understanding on their therapeutic effects, it's critical to unveil chemical compositions of TCM formula, the predominant form of therapy in TCM. However,(More)
Compound identification is the essential step in the mechanistic research of traditional Chinese medicine (TCM). As the most common mode of practice in the clinic, TCM formula (Fangji or FJ in Chinese) is often utilized to treat diseases. With the proved therapeutic efficacies by century-long clinical applications, these TCM formulas have been the valuable(More)
Lipase inhibitors generate hypolipidemic effect that is helpful to control or treat some obesity diseases by inactivating catalytic activity of human pancreatic lipase, a key enzyme involved in triglyceride hydrolysis in vivo. Many traditional Chinese medicine (TCM) formulae have been effectively used to treat obesity and other fat related diseases for(More)
In comparison with monotherapy in western medicine, traditional Chinese medicine (TCM) advocates combinational therapy for treating diseases and TCM formula is a representative for this approach. Despite of extensive clinical applications of TCM formulae, knowledge about their pharmacological activities, mechanisms of action and cellular targets remains(More)
i Acknowledgements I would like to acknowledge my committee members John Lamb, Robert Blanchette, and advisor Senyu Chen for their helpful feedback and input on my research and thesis. Additionally, I would like to thank my advisor Senyu Chen for giving me the opportunity to conduct research on nematodes and, in many ways, for making the research possible.(More)