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Violacein and the indolocarbazoles are naturally occurring bisindole products with various biological activities, including antitumor activity. Although these compounds have markedly different… Expand
The diversity of indolocarbazole natural products results from the differences in oxidation states of the pyrroline ring moiety. In the biosynthetic pathways for staurosporine and rebeccamycin, two… Expand
Staurosporine isolated from Streptomyces sp. TP-A0274 is a member of the family of indolocarbazole alkaloids that exhibit strong antitumor activity. A key step in staurosporine biosynthesis is the… Expand
Indole-3-pyruvic acid was transformed to chromopyrrolic acid by a novel heme-containing enzyme StaD responsible for staurosporine biosynthetic pathway in Streptomyces sp. TP-A0274.
The pseudo-glycosyltransferase VldE catalyzes non-glycosidic C-N coupling between an unsaturated cyclitol and a saturated aminocyclitol with the conservation of the stereochemical configuration of… Expand
Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; Furumai, T. Biosci. Biotechnol. Biochem.… Expand
Abstract Indole-3-pyruvic acid is transformed to prodeoxyviolacein by the novel enzyme VioE, which is involved in the violacein biosynthetic pathway in Chromobacterium violaceum ATCC12472. VioE… Expand