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  • Satoshi Hirano, Shumpei Asamizu, Hiroyasu Onaka, Yoshitsugu Shiro, Shingo Nagano
  • Chemistry, Medicine
  • Journal of Biological Chemistry
  • 2008 (First Publication: 7 March 2008)
  • Violacein and the indolocarbazoles are naturally occurring bisindole products with various biological activities, including antitumor activity. Although these compounds have markedly differentExpand
  • Shumpei Asamizu, Yoshitsugu Shiro, Yasuhiro Igarashi, Shingo Nagano, Hiroyasu Onaka
  • Biology, Medicine
  • Bioscience, biotechnology, and biochemistry
  • 2011 (First Publication: 23 November 2011)
  • The diversity of indolocarbazole natural products results from the differences in oxidation states of the pyrroline ring moiety. In the biosynthetic pathways for staurosporine and rebeccamycin, twoExpand
  • Masatomo Makino, Hiroshi Sugimoto, Yoshitsugu Shiro, Shumpei Asamizu, Hiroyasu Onaka, Shingo Nagano
  • Chemistry, Medicine
  • Proceedings of the National Academy of Sciences
  • 2007 (First Publication: 10 July 2007)
  • Staurosporine isolated from Streptomyces sp. TP-A0274 is a member of the family of indolocarbazole alkaloids that exhibit strong antitumor activity. A key step in staurosporine biosynthesis is theExpand
  • Y. Wang, H. Chen, +5 authors S. Shaik
  • Chemistry, Medicine
  • Journal of the American Chemical Society
  • 2009 (First Publication: 22 April 2009)
  • Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; Furumai, T. Biosci. Biotechnol. Biochem.Expand