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Myosin motors are central to diverse cellular processes in eukaryotes. Homologues of the myosin chaperone UNC-45 have been implicated in the assembly and function of myosin-containing structures in organisms from fungi to humans. In muscle, the assembly of sarcomeric myosin is regulated to produce stable, uniform thick filaments. Loss-of-function mutations(More)
The tripartite symbiosis between legumes, rhizobia and mycorrhizal fungi are generally considered to be beneficial for the nitrogen (N) uptake of legumes, but the facilitation of symbiosis in legume/non-legume intercropping systems is not clear. Therefore, the aims of the research are as follows: (1) to verify if the dual inoculation can facilitate the N(More)
AIMS Transforming growth factor-beta1 (TGF-beta1) is a multifunctional cytokine that contributes to pathogenic cardiac remodelling via mechanisms that involve oxidative stress. However, the direct impact of TGF-beta1 on contractile function of ventricular myocytes is incompletely understood. METHODS AND RESULTS Reactive oxygen species (ROS) production and(More)
Oxidative stress and the resulting change in cell redox state are proposed to contribute to pathogenic alterations in ion channels that underlie electrical remodeling of the diseased heart. The present study examined whether K(+) channel remodeling is controlled by endogenous oxidoreductase systems that regulate redox-sensitive cell functions. Diabetes was(More)
Duchenne muscular dystrophy (DMD) is a fatal degenerative muscle disease resulting from mutations in the dystrophin gene. Increased oxidative stress and altered Ca(2+) homeostasis are hallmarks of dystrophic muscle. While impaired autophagy has recently been implicated in the disease process, the mechanisms underlying the impairment have not been(More)
Production of reactive oxygen species (ROS) has been implicated in the pathology of many conditions, including cardiovascular, inflammatory and degenerative diseases, aging, muscular dystrophy, and muscle fatigue. NADPH oxidases (Nox) have recently gained attention as an important source of ROS involved in redox signaling. However, our knowledge of the(More)
For the solution to ∂ 2 t u(x, t) − △u(x, t) + q(x)u(x, t) = δ(x1)δ ′ (t) and u|t<0 = 0, we consider an inverse problem of determining q(x), x ∈ Ω from data f = u|S T and g = ∂u ∂ν T > 0. For suitable T > 0, we prove an L 2 (Ω)-size estimation of q: q L 2 (Ω) ≤ C n f H 1 (S T) + g L 2 (S T) o , provided that q satisfies a priori uniform boundedness(More)
Let u = u(q) satisfy a hyperbolic equation with impulsive input: ∂ 2 t u(x, t) − u(x, t) + q(x)u(x, t) = δ(x 1)δ (t) and let u| t<0 = 0. Then we consider an inverse problem of determining q(x), x ∈ Ω from data u(q)| S T and (∂u(q)/∂ν) | S T. Here Ω ⊂ {(x 1 ,. .. , x n) ∈ R n |x 1 > 0}, n ≥ 2, is a bounded domain, S T = {(x, t); x ∈ ∂Ω, x1 < t < T + x1}, ν =(More)