Shumei Xu

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β-amyloid hypothesis is the predominant hypothesis in the study of pathogenesis of Alzheimer's disease. This hypothesis claims that aggregation and neurotoxic effects of amyloid β (Aβ) is the common pathway in a variety of etiological factors for Alzheimer's disease. Aβ peptide derives from amyloid precursor protein (APP). β-sheet breaker peptides can(More)
H102, a novel β-sheet breaker peptide, was encapsulated into liposomes to reduce its degradation and increase its brain penetration through intranasal administration for the treatment of Alzheimer’s disease (AD). The H102 liposomes were prepared using a modified thin film hydration method, and their transport characteristics were tested on Calu-3 cell(More)
The abundance of protein and its functional diversity in living systems makes it essential for virtually all life processes. Dietary protein and amino acid requirements are affected by age, body size, body composition, physiological state, and the level of energy output. The requirement for dietary protein is based on the indispensable amino acids under all(More)
OBJECTIVE To observe the influence of H102 on the expression of amyloid protein and amyloid precursor protein in the hippocampus of APP695 transgenic mice. METHODS The 9-month-old APP695 transgenic mice were randomly divided into the model group and the H102 group; C57BL/6J mice were adopted as normal control group. The H102 group were injected with H102(More)
AIM To study the effect of bupleurum root on epileptic seizure. METHODS The rabbits and rats were injected by pilocarpine as epileptic models, and observed the effect of bupleurum on the electroencephalogram (EEG) and hippocampal slice by electroencephalograph and glass microelectrode extracellularly. RESULTS The seizure time and duration of each major(More)
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