Shukun Hu

Learn More
Autophagy occurs in the brain after intracerebral hemorrhage (ICH) and thrombin contributes to ICH-induced brain injury and cell death. In this study, we investigated whether thrombin may activate autophagy (in vivo and in cultured astrocytes) and its potential role in ICH. Autophagy was examined using electron microscopy, conversion of light chain 3(LC3)(More)
Magnetic resonance imaging (MRI) has been widely used in intracerebral hemorrhage (ICH) animal models and patients. In the current study, we examined whether MRI can predict at-risk brain tissue during the acute phase and long-term brain tissue loss after ICH. Male Sprague-Dawley rats had an intracaudate injection of autologous whole blood (10, 50 or 100(More)
Circadian rhythm disorder is a common neurological deficit caused by neonatal hypoxic-ischemic brain damage (HIBD). However, little is known about its underlying mechanisms. Our previous studies revealed a significant elevation of clock genes at the protein, but not mRNA, levels in the pineal gland after neonatal HIBD. To investigate the mechanisms of(More)
Autophagy widely occurs after intracerebral hemorrhage (ICH). In our previous study, we demonstrated that thrombin, a serine protease produced after hematoma, contributes to ICH-induced autophagy. However, whether thrombin plays a neuronal and/or astrocytic role in autophagy induction is largely unknown. Here, we examined the autophagic role of thrombin on(More)
  • 1