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Amelioration of hepatic steatosis is associated with modulation of gut microbiota and suppression of hepatic miR-34a in Gynostemma pentaphylla (Thunb.) Makino treated mice
TLDR
The results suggested that GP modulated the gut microbiota and suppressed hepatic miR-34a, which was associated with the amelioration of hepatic steatosis.
Downregulation of esophageal cancer-related gene 4 promotes proliferation and migration of hepatocellular carcinoma
TLDR
The results of the present study indicated that ECRG4 was downregulated in HCC and served important roles in promoting cell proliferation and migration.
Intercellular adhesion molecule 1 is a sensitive and diagnostically useful immunohistochemical marker of papillary thyroid cancer (PTC) and of PTC-like nuclear alterations in Hashimoto's thyroiditis
TLDR
It is demonstrated that ICAM-1 expression is upregulated in papillary thyroid cancer and in Hashimoto's thyroiditis with PTC-like nuclear alterations, which may be an important factor in the progression of cancer of the thyroid gland.
Natural history of mild subclinical hypothyroidism in a middle-aged and elderly Chinese population: a prospective study.
TLDR
TPOAb and TC seem to be more important predictors of progression to OH than initial thyrotropin, whereas high baseline thyrotopin or CR were negative correlated with reversion to euthyroidism.
HCRP1, ID4 and Glypican-3: an optimal panel of biomarkers for diagnosis of hepatocellular carcinoma.
TLDR
HCRP1 and ID4 represent potentially novel valuable biomarkers for distinguishing HCC from benign liver nodules, and it is recommended to use the combination of H CRP1, ID4 and GPC-3 as a panel in HCC differentiation estimation.
Strengthening the detail management and improving the integrity of medical scientific research
TLDR
To improve the scientific research management mechanism, it is suggested to further develop the research integrity education, update and specify the management system of scientific research integrity, refine the research management process, strengthen the monitoring of scientificResearch funds, reinforce medical ethics training and construct more systematic scientific research performance evaluation.
Utility of an immunostaining panel for diagnosis of hepatocellular carcinoma in fine needle-aspiration biopsies of the liver
TLDR
This study demonstrates that Arginase-1 is an extremely effective and specific immunohistochemistry marker for confirming hepaticorigin, while GPC-3 and HSP70 is typically positive in malignant lesions.