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Cancer‐associated upregulation of histone H3 lysine 9 trimethylation promotes cell motility in vitro and drives tumor formation in vivo
Global histone modification patterns correlate with tumor phenotypes and prognostic factors in multiple tumor types. Recent studies suggest that aberrant histone modifications play an important role… Expand
SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3.
- Yoshimi Shinchi, M. Hieda, +5 authors N. Matsuura
- Biology, Medicine
- Experimental cell research
- 15 May 2015
The genome-wide loss of histone H4 lysine 20 tri-methylation (H4K20me3) is observed in multiple types of cancer, including breast tumors. Since H4K20me3 is preferentially targeted to repetitive… Expand
Nuclear envelope-localized EGF family protein amphiregulin activates breast cancer cell migration in an EGF-like domain independent manner.
- H. Tanaka, Yu Nishioka, +4 authors M. Hieda
- Biology, Medicine
- Biochemical and biophysical research…
- 20 April 2012
Amphiregulin (AREG), an EGF family protein, is synthesized as a type I transmembrane precursor (proAREG) and expressed on the cell surface with an extracellular EGF-like domain and an intracellular… Expand
Identification of potential breast cancer markers in nipple discharge by protein profile analysis using two‐dimensional nano‐liquid chromatography/nanoelectrospray ionization‐mass spectrometry
- S. Kurono, Yuka Kaneko, +8 authors Shuji Matsuura
- Proteomics. Clinical applications
- 26 April 2016
This research aimed to establish a diagnostic technique for breast cancer using nipple discharge (ND), with the objective of preventive diagnosis. ND has been proposed as a source of secreted… Expand
Quantification of proteins using (13)C7-labeled and unlabeled iodoacetanilide by nano liquid chromatography/nanoelectrospray ionization and by selected reaction monitoring mass spectrometry.
- S. Kurono, Yuka Kaneko, Shuji Matsuura, S. Niwayama
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 1 March 2015
The combination of cysteine-specific modifiers, iodoacetanilide (IAA) and (13)C7-labeled iodoacetanilide ((13)C7-IAA), has been applied to absolute quantification of proteins. The selected reaction… Expand
Cancer associated up‐regulation of H3K9 trimethylation. Increased H3K9me3 levels in the invasive region of colorectal cancer tissue. See also Yokoyama, Y., et al.
The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal
The morphology of the Golgi complex is influenced by the cellular context, which strictly correlates with nuclear functions; however, the mechanism underlying this association remains elusive. The… Expand