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Cancer‐associated upregulation of histone H3 lysine 9 trimethylation promotes cell motility in vitro and drives tumor formation in vivo
It is shown that the histone H3 lysine 9 (H3K9) methyltransferase SUV39H1 is clearly involved in regulating cell migration in vitro and plays an important role in human colorectal cancer progression, possibly by promoting collective cell invasion.
SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3.
Nuclear envelope-localized EGF family protein amphiregulin activates breast cancer cell migration in an EGF-like domain independent manner.
Identification of potential breast cancer markers in nipple discharge by protein profile analysis using two‐dimensional nano‐liquid chromatography/nanoelectrospray ionization‐mass spectrometry
ND has been proposed as a source of secreted proteomes that reflect early pathological changes in the ductal‐lobular epithelial microenvironment, and could thus provide breast‐specific cancer biomarkers that could be accessed noninvasively as a new clinical diagnostic technique.
The SUN2-nesprin-2 LINC complex and KIF20A function in the Golgi dispersal
It is found that depletion of SUN1 leads to Golgi complex dispersion with maintenance of ministacks and retained function for vesicle transport through the Golgi Complex, suggesting that SUN1 suppresses the function of the SUN2-nesprin-2 LINC complex under a steady-state condition.
Quantification of proteins using (13)C7-labeled and unlabeled iodoacetanilide by nano liquid chromatography/nanoelectrospray ionization and by selected reaction monitoring mass spectrometry.