Shuji Kaneshima

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A comparative light microscopic and scanning electron microscopic study of the morphogenesis of peritoneal metastasis in 34 human gastric cancers was performed. Prior to adhesion of gastric cancer cells to the peritoneum, the mesothelial cells became hemispherical and exfoliated from the peritoneum, and gastric cancer cells adhered to the naked areas of the(More)
Free cancer cells in the peritoneal cavity of 100 patients with gastric cancer were examined by means of Douglas lavage, and their viability was estimated by 3H-thymidine uptake with autoradiographical technic. Furthermore, the effect of mitomycin-C on the viability of free cancer cells in the peritoneal cavity was studied. The appearance of intraperitoneal(More)
Blood-brain barrier (BBB) disruption occurs frequently in CNS diseases and injuries. Few drugs have been developed as therapeutic candidates for facilitating BBB functions. Here, we examined whether metformin up-regulates BBB functions using rat brain microvascular endothelial cells (RBECs). Metformin, concentration- and time-dependently increased(More)
The process and mechanism of peritoneal metastasis of tumor cells were studied experimentally by means of scanning or transmission electron microscopy, employing rat ascites hepatoma AH100B. Adhesion of tumor cells by microvilli and/or pseudopodia to the mesothelium was observed within 1 approximately 3 days after inoculation when there was no morphological(More)
The viability and morphologic changes of intraperitoneal free cancer cells in advanced gastric cancer patients were examined by Giemsa and enzymologic staining and by tritiated thymidine uptake. Although many free cancer cells in the pouch of Douglas showed moderate degeneration, viable, morphologically intact cells were noted, leading to the possibility of(More)
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