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Discovery of Replicating Circular RNAs by RNA-Seq and Computational Algorithms
TLDR
It is proposed that these computational algorithms have the potential to discover novel circular RNAs in plants, invertebrates and vertebrates regardless of whether they replicate and/or induce the in vivo accumulation of small RNAs.
Ecogenomic survey of plant viruses infecting Tobacco by Next generation sequencing
TLDR
This study describes the discovery of a consortium of plant viruses infecting Tobacco that are broadly distributed in Anhui province of China and demonstrates the effectiveness of NGS in identifying plant viruses without a prior knowledge of the virus and the genetic diversity that enhanced mixed infection.
Complete genome sequence of a novel velarivirus infecting areca palm in China
The complete genome of a novel virus, provisionally named areca palm velarivirus 1 (APV1), was identified in areca palm exhibiting leaf yellowing symptoms in Hainan province, China. The genome of
Complete genome sequence of tobacco virus 1, a closterovirus from Nicotiana tabacum
TLDR
This study is the first report of the complete genome sequence of a closterovirus identified in tobacco, containing nine open reading frames (ORFs) that potentially encode proteins with putative functions in virion assembly, cell-to-cell movement and suppression of RNA silencing.
Network Pharmacology-Based Mechanistic Investigation of Jinshui Huanxian Formula Acting on Idiopathic Pulmonary Fibrosis
TLDR
In vivo experiments showed that JHF alleviated the degree of PF, including decreases in collagen deposition and epithelial-mesenchymal transition, and elucidates the potential roles and mechanisms of JHF in IPF therapy.
Network pharmacology-based mechanistic investigation of Jinshui Huanxian formula acing on idiopathic pulmonary fibrosis
TLDR
In vivo experiments showed that JHF could alleviate the degree of pulmonary fibrosis, including the decrease of collagen deposition and epithelial-mesenchymal transition, and Pharmacological network with in vivo validation explained the potential roles and mechanisms of JHF in IPF therapy.