Learn More
Changes in glycosylation due to specific alterations of glycosyltransferase activity have been shown in various tumor cells, including human glioma cells. β1,3-N‑acetylglucosaminyltransferase-8 (β3GnT8) catalyzes the formation of polylactosamine on β1-6 branched N-glycans. Upregulated expression of β3GnT8 was described in some tumors, but its precise role(More)
Aberrant carbohydration by related glycosyl-transferases plays an important role in the progression of cancer. This study focused on the ablity of β-1,3-N-acetyl-glucosaminyltransferase-8 (β3GnT8) to regulate MMP-2 expression through regulation of the CD147 signal transduction pathway in cancer cells. β3GnT8 catalyzes and then extends a polylactosamine(More)
Alterations to N‑linked glycans are closely associated with cancer progression. Of particular importance in tumor growth and invasion, is the synthesis of complex N‑linked oligosaccharides containing poly‑N‑acetyllactosamine (polylactosamine) chains, which have previously been reported to inhibit 3'‑azidothymidine (AZT). Cluster of differentiation 147(More)
  • 1