Shuhei Yoshimoto

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Renal α-Klotho (α-KL) plays a fundamental role as a co-receptor for fibroblast growth factor 23 (FGF23), a phosphaturic hormone and regulator of 1,25(OH)2 vitamin D3 (1,25VitD3). Disruption of FGF23-α-KL signaling is thought to be an early hallmark of chronic kidney disease (CKD) involving reduced renal α-KL expression and a reciprocal rise in serum FGF23.(More)
Tidal response method is an efficient technique for investigating hydraulic properties of an aquifer in insular and coastal areas of highly permeable geological settings. The present study extends a simple and straightforward harmonic-analysis technique recently introduced as part of a tidal response method applied to a freshwater-lens aquifer. This simple(More)
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that causes inflammatory tissue damage, including lupus nephritis and vasculitis. Local generation of adhesion molecules and expression of their ligands on inflammatory cells appears to contribute to the progression of SLE. We found significantly increased E-selectin expression in the(More)
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