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Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein.
Autophagy is a bulk, nonspecific protein degradation pathway that is involved in the pathogenesis of cancer and neurodegenerative disease. Here, we observed that xanthohumol (XN), a prenylatedExpand
Synthesis and assignment of the absolute configuration of indenotryptoline bisindole alkaloid BE-54017.
Synthesis of the indenotryptoline bisindole alkaloid, BE-54017, was accomplished using osmium-promoted cis-dihydroxylation of maleimide as a key step. After optical resolution, the absoluteExpand
Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin‐containing protein inhibitor
Xanthohumol (XN), a simple prenylated chalcone, can be isolated from hops and has the potential to be a cancer chemopreventive agent against several human tumor cell lines. We previously identifiedExpand
Hydroxypropyl Cyclodextrin Improves Amiodarone-Induced Aberrant Lipid Homeostasis of Alveolar Cells.
Alveolar epithelial type II (AT2) cells secrete pulmonary surfactant via lamellar bodies (LBs). Abnormalities in LBs are associated with pulmonary disorders, including fibrosis. However, high-contentExpand
Directed induction of alveolar type I cells derived from pluripotent stem cells via Wnt signaling inhibition
Alveologenesis is a developmental step involving the expansion of the lung surface area which is essential for gas exchange. The gas exchange process is mediated by alveolar type I (AT1) cells, whichExpand
Abstract C18: Antitumor activity of xanthohumol, an inhibitor of valosin-containing protein.
Autophagy is a bulk, nonspecific protein degradation pathway that is involved in the pathogenesis of cancer and neurodegenerative disease. Here, we observed that xanthohumol (XN), a prenylatedExpand