d-Amino Acids Trigger Biofilm Disassembly
- Ilana Kolodkin-Gal, D. Romero, Shugeng Cao, J. Clardy, R. Kolter, R. Losick
- BiologyScience
- 30 April 2010
It is found that d-amino acids found in conditioned medium from mature biofilms of Bacillus subtilis prevent biofilm formation and trigger existing biofilm disassembly, and may be a widespread signal for bio Film disassembly.
Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer
ATRA-induced Pin1 ablation simultaneously blocks multiple Pin1-regulated cancer-driving pathways, an attractive property for treating aggressive and drug-resistant tumors.
Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine
- K. Briggs, P. Koivunen, W. Kaelin
- BiologyCell
- 30 June 2016
Lassomycin, a ribosomally synthesized cyclic peptide, kills mycobacterium tuberculosis by targeting the ATP-dependent protease ClpC1P1P2.
- E. Gavrish, C. S. Sit, K. Lewis
- Biology, ChemistryChemistry and Biology
- 24 April 2014
A Bacillus subtilis sensor kinase involved in triggering biofilm formation on the roots of tomato plants
- Yun Chen, Shugeng Cao, R. Losick
- BiologyMolecular Microbiology
- 1 August 2012
It is proposed that small signalling molecules released by the roots of tomato plants are directly or indirectly recognized by KinD, triggering biofilm formation, and this requires genes governing the production of the extracellular matrix that holds cells together.
Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis.
- M. Hiraki, So‐Young Hwang, Sam W. Lee
- Biology, ChemistryChemistry and Biology
- 1 August 2015
Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria
- Joshua A. V. Blodgett, D. Oh, Shugeng Cao, C. Currie, R. Kolter, J. Clardy
- BiologyProceedings of the National Academy of Sciences
- 14 June 2010
The prevalence of frontalamide-like gene clusters in diverse bacterial types, with medicinally important Streptomyces species being particularly enriched, is established.
A self-produced trigger for biofilm disassembly that targets exopolysaccharide.
- Ilana Kolodkin-Gal, Shugeng Cao, R. Losick
- BiologyCell
- 2012
Cytotoxic triterpenoid saponins of Albizia gummifera from the Madagascar rain forest.
- Shugeng Cao, Andrew Norris, D. Kingston
- ChemistryJournal of Natural Products
- 31 January 2007
Three new cytotoxic oleanane-type triterpenoid saponins, gummiferaosides A-C, showed cytotoxicity against the A2780 human ovarian cancer cell line with IC50 values of 0.8, 1.5, and 0.6 microg/mL, respectively.
A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals
- R. Alegado, L. C. Brown, N. King
- BiologyeLife
- 18 July 2012
This study provides a prototypical example of bacterial sulfonolipids triggering eukaryotic morphogenesis and suggests molecular mechanisms through which bacteria may have contributed to the evolution of animals.
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