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Asymmetric Total Syntheses of Aspidodasycarpine, Lonicerine, and the Proposed Structure of Lanciferine.
The proposed structure of lanciferine, a highly oxidized congener of aspidodasycarpine, was synthesized from the lactol by tuning the oxidation states of various carbons.
Assembly of a Metalloporphyrin-Polyoxometalate Hybrid Material for Highly Efficient Activation of Molecular Oxygen.
- Shugao Zhu, Xuan Xu, Shaomin Ou, Min Zhao, Wei-Long He, Chuande Wu
- ChemistryInorganic chemistry
- 13 July 2016
A "step-by-step" aggregation strategy is developed that demonstrates that the collaborative work of multiple active sites in hybrid materials can achieve superior high efficiency in heterogeneous catalysis.
Gold-catalyzed cyclization of 3-(2'-azidoaryl)-1-arylpropargyl carbonates or 3-aryl-1-(2'-azidoaryl)propargyl carbonates to produce quinolines.
A gold-catalyzed cyclization of 3-(2'-azidoaryl)-1-arylpropargyl carbonates to generate substituted quinolines via a sequence of 3,3-rearrangement, 6-endo-trig cyclization and denitrogenation has…
Palladium-Catalyzed Sequential Reactions via Allene Intermediates for the Rapid Synthesis of Fused Polycyclic Pyrrole Derivatives
In this paper, we report a novel sequential reaction sequence consisting of a series of processes including Sonogashira coupling, propargyl-allenyl isomerization, [3 + 2] cycloaddition,…
Total Synthesis of Trioxacarcins DC-45-A1, A, D, C, and C7″-epi-C and Full Structural Assignment of Trioxacarcin C.
- K. Nicolaou, Q. Cai, Hongbao Sun, Bo-Wen Qin, Shugao Zhu
- ChemistryJournal of the American Chemical Society
- 24 February 2016
The gathered knowledge sets the foundation for the design, synthesis, and biological evalution of analogues of these natural products as potential payloads for antibody-drug conjugates and other delivery systems for targeted and personalized cancer chemotherapy.
Gold(I)‐Catalyzed Decarboxylation of Propargyl Carbonates: Reactivity Reversal of the Gold Catalyst from π‐Lewis Acidity to σ‐Lewis Acidity
A cationic gold(I)-catalyzed decarboxylative etherification of propargyl carbonates to selectively produce propargyl ethers is reported. In the reaction the gold(I) catalyst shows a distinct σ-Lewis…
A Remarkable Ene-Like Reaction: Development and Synthetic Applications
Abstract A catalytic ene-like reaction of aldehydes with those vinyl ethers that display the oxygen functionality at the central carbon of an allylic system, e.g., 2-methoxypropene, is discussed in…
Unexpected Pd-catalyzed coupling, propargyl-allenyl isomerization and alder-ene reaction: facile synthesis of some not readily available 2,3-dihydrofuran derivatives.
An interesting sequential reaction involving Pd-catalyzed coupling, propargyl-allenyl isomerization, and Alder-ene cycloaddition is reported, providing a facile synthesis of some not readily…
Palladium(0)-catalyzed cyclization of 1,6-diyn-3-yl carbonates with a nucleophilic functionality: efficient synthesis of polycyclic benzo[b]fluorene derivatives via allene intermediates.
We report in this paper an interesting tandem reaction involving sequential palladium(0)-catalyzed decarboxylation of diynylic carbonates, intramolecular nucleophilic cyclization and Schmittel…
Synthesis of polycyclic isoindoline derivatives via tandem Pd-catalyzed coupling, propargyl-allenyl isomerization, [4 + 2] cycloaddition and aromatization reaction.
We report in this paper an interesting sequential reaction involving sequential Sonogashira coupling, propargyl-allenyl isomerization, [4 + 2] cycloaddition and aromatization reaction, which provides…