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Vasoactive intestinal peptide re-balances TREM-1/TREM-2 ratio in acute lung injury
TLDR
The results suggest that VIP might exert its anti-inflammatory effect through a mechanism involved in regulation of expression of the TREM-1 and T REM-2 in LPS-induced ALI.
CXCR2 is involved in pulmonary intravascular macrophage accumulation and angiogenesis in a rat model of hepatopulmonary syndrome.
TLDR
During HPS pathogenesis in rats, CXCR2 might be involved in the accumulation of pulmonary intravascular macrophages and angiogenesis, possibly by activating Akt and ERK, with additional regulation by TNF-α that enhanced pulmonary angiogenic by directly acting on the pulmonary tissue.
Protective effects of exercise on endotoxin-induced acute lung injuries in obese rats
Background: The aim of this study was to investigate the effects of exercise on endotoxin-induced acute lung injuries in obese rats. Methods: Male Sprague-Dawley rats were randomly divided into three
The therapeutic effect of verapamil in lipopolysaccharide-induced acute lung injury.
TLDR
Findings indicate that Verapamil has a therapeutic effect on LPS-induced ALI in mice, related to the inhibition of NF-κB and NLRP3 signaling pathways, and may be a potential therapeutic agent for the treatment of ALI.
TRIM37 negatively regulates inflammatory responses induced by virus infection via controlling TRAF6 ubiquitination.
TLDR
TRIM37 deficiency reduced the levels of virous proinflammatory cytokines in bone marrow derived macrophages (BMDMs).
Schisandrin A protects against isoproterenol-induced chronic heart failure via miR-155
  • Lijing Gao, Ting Li, Shufen Li, Zhuohui Song, Yongli Chang, Li Yuan
  • Medicine
    Molecular medicine reports
  • 22 November 2021
TLDR
Schisandrin A mediated the AKT/CREB signaling pathway to prevent CHF by regulating the expression of miR-155, which may shed light on a possible therapeutic target for CHF.
Mir-204 Regulates LPS-Induced A549 Cell Damage by Targeting FOXK2
Objective To assess whether miR-204 and HA affect A549 cell injury induced by lipopolysaccharide. Material and Methods. A549 cells were treated with hirsutanol A, and cell damage was induced by LPS