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Oncogenic KRAS mutations found in 20% to 30% of all non–small cell lung cancers (NSCLC) are associated with chemoresistance and poor prognosis. Here we demonstrate that activation of the cell protective stress response gene NRF2 by KRAS is responsible for its ability to promote drug resistance. RNAi-mediated silencing of NRF2 was sufficient to reverse(More)
The photothermal effect of plasmonic nanostructures has numerous applications, such as cancer therapy, photonic gene circuit, large cargo delivery, and nanostructure-enhanced laser tweezers. The photothermal operation can also induce unwanted physical and biochemical effects, which potentially alter the cell behaviors. However, there is a lack of techniques(More)
In the last seven years, optoelectronic tweezers using optically-induced dielectrophoretic (ODEP) force have been explored experimentally with much success in manipulating micro/nano objects. However, not much has been done in terms of in-depth understanding of the ODEP-based manipulation process or optimizing the input physical parameters to maximize ODEP(More)
We report in this paper a novel, inexpensive and flexible method for fabricating micrometer-and nanometer-scale three-dimensional (3D) polymer structures using visible light sources instead of ultraviolet (UV) light sources or lasers. This method also does not require the conventional micro-photolithographic technique (i.e., photolithographic masks) for(More)
At the onset of collective cell migration, a subset of cells within an initially homogenous population acquires a distinct 'leader' phenotype with characteristic morphology and motility. However, the factors driving the leader cell formation as well as the mechanisms regulating leader cell density during the migration process remain to be determined. Here(More)
We have developed a simple, inexpensive and flexible method to automatically manipulate and assemble micro-/nano-entities using optically-induced dielectrophoretic (ODEP) force. Instead of using traditional fixed metal microelectrodes to generate non-uniform electric field, dynamic optical images designed by an animator software and projected through a(More)
Acrylamide (ACR) is a vinyl monomer with established human neurotoxic effects, which is characterized by the accumulation of neurofilaments (NFs) in the distal swellings of large axons in peripheral and central nervous systems. However, the mechanisms of neurotoxicity remain unclear. The objective is to investigate the neuroprotective effect of calpeptin(More)
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