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BACKGROUND Systemic lupus erythematosus (SLE) is a chronic heterogeneous disease with considerable burden from disease activity and damage. A novel clinical treatment target in the form of the lupus low disease activity state (LLDAS) has been recently reported, with retrospective validation showing that time spent in LLDAS translates to reduced damage(More)
BACKGROUND Systemic lupus erythematosus (SLE) is associated with significant impairment of health-related quality of life (HR-QoL). Recently, meeting a definition of a lupus low disease activity state (LLDAS), analogous to low disease activity in rheumatoid arthritis, was preliminarily validated as associated with protection from damage accrual. The LLDAS(More)
Pathological observations on brain damage in baby rats with experimental copper deficiency were carried out and the following observations were made: 1. The cerebrum were decreased in size and weight, the cortex became thinner and the corpus striatum atrophic. 2. Vacuolar degeneration and swelling of the mitochondria in the extrapyramidal system within the(More)
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