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The growth of the vocal tract (VT) is known to be non-uniform insofar as there are regional differences in anatomic maturation. This study presents quantitative anatomic data on the growth of the oral and pharyngeal portions of the VT from 605 imaging studies for individuals between birth and 19 years. The oral (horizontal) portion of the VT was segmented(More)
PURPOSE The anatomic origin for prepubertal vowel acoustic differences between male and female subjects remains unknown. The purpose of this study is to examine developmental sex differences in vocal tract (VT) length and its oral and pharyngeal portions. METHOD Nine VT variables were measured from 605 imaging studies (magnetic resonance imaging and(More)
Inhibition of hepatic transporters such as organic anion transporting polypeptides (OATPs) 1B can cause drug-drug interactions (DDIs). Determining the impact of perpetrator drugs on the plasma exposure of endogenous substrates for OATP1B could be valuable to assess the risk for DDIs early in drug development. As OATP1B orthologs are well conserved between(More)
RATIONALE AND OBJECTIVES Head circumference (HC) is an important developmental measure used both clinically and in research. This paper advances a method to estimate HC from imaging studies when a direct HC-tape measurement cannot be secured. Unlike former approaches, the model takes into account the fact that growth is nonlinear, and that HC growth rates(More)
We explored the possibility of developing an automatic diagnostic tool for detecting autism based on MRI measurements. Since the two previous structural imaging studies [1] [2] strongly suggested there were significant abnormality in the corpus callosum (CC) region, the methodology is concentrated in this area. For this purpose , we have developed a new(More)
Although there are numerous publications on amygdala vol-umetry, so far there has not been many studies on modeling local amyg-dala surface shape variations in a rigorous framework. This paper present a systematic framework for modeling local amygdala shape. Using a novel surface flattening technique, we obtain a smooth mapping from the amygdala surface to(More)
SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription factors SREBP-1 and -2. SREBPs regulate the expression of genes involved in fatty acid and cholesterol biosynthesis, and LDL-C clearance through the(More)
Rheumatoid arthritis (RA) is a chronic autoimmune disease resulting in joint inflammation, pain, and eventual bone loss. Bone loss and remodeling caused by symmetric polyarthritis, the hallmark of RA, is readily detectable by bone mineral density (BMD) measurement using micro-CT. Abnormalities in these measurements over time reflect the underlying(More)