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Significance and Determinants of Cardiac Troponin I in Patients With Obstructive Hypertrophic Cardiomyopathy.
TLDR
Serum cTnI is associated with multiple parameters of disease severity, suggesting its great significance in assessing cardiac remodeling in patients with obstructive HC. Expand
AMPK/PGC1&agr; activation by melatonin attenuates acute doxorubicin cardiotoxicity via alleviating mitochondrial oxidative damage and apoptosis
TLDR
AMPK/PGC1&agr; pathway activation may represent a new mechanism for melatonin exerted protection against acute DOX cardiotoxicity through preservation of mitochondrial homeostasis and alleviation of oxidative stress and apoptosis. Expand
Follow-up by cardiac magnetic resonance imaging in patients with hypertrophic cardiomyopathy who underwent percutaneous ventricular septal ablation.
TLDR
In conclusion, cardiac magnetic resonance imaging allowed a detailed evaluation of the size and location of septal myocardial infarction induced by PVSA, and the left ventricularMyocardial mass decreased significantly during the follow-up period. Expand
PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades
TLDR
Results indicate that pterostilbene protects cardiomyocytes from acute DOX exposure-induced oxidative stress and mitochondrial damage via PGC1α upregulation and deacetylation through activating AMPK and SIRT1 cascades. Expand
Predictive Values of N-Terminal Pro-B-Type Natriuretic Peptide and Cardiac Troponin I for Myocardial Fibrosis in Hypertrophic Obstructive Cardiomyopathy
TLDR
Serum cTnI is an independent predictor useful for identifying myocardial fibrosis, while plasma NT- Pro-B-Type Natriuretic Peptide is only associated with my cardiac fibrosis on univariate analysis. Expand
Procollagen type I carboxy-terminal propeptide (PICP) and MMP-2 are potential biomarkers of myocardial fibrosis in patients with hypertrophic cardiomyopathy.
TLDR
In patients with HCM, plasma PICP and MMP-2 levels quantitatively reflect myocardial fibrosis, suggesting that PICp and M MP-2 may be used as reliable BMFs. Expand
Characteristics of Myocardial Postsystolic Shortening in Patients with Symptomatic Hypertrophic Obstructive Cardiomyopathy before and Half a Year after Alcohol Septal Ablation Assessed by Speckle
TLDR
PTSMA has a favourable effect on PSS, which may partly account for the persistent improvement in LV diastolic function in HOCM patients after PTSMA. Expand
Evaluation of Left Ventricular Diastolic Function by Global Strain Rate Imaging in Patients with Obstructive Hypertrophic Cardiomyopathy: A Simultaneous Speckle Tracking Echocardiography and Cardiac
TLDR
Speckle tracking echocardiography (STE) provides direct information on intrinsic myocardial function and may improve the diagnostic of diastolic dysfunction in HCM patients. Expand
Implantation of autologous bone marrow mononuclear cells into ischemic myocardium enhances coronary capillaries and systolic function in miniswine.
TLDR
Transplantation of BM-MNC into myocardium with ischemic reperfusion injury increases capillary density and decreases infarction area, which has significantly beneficial effect on cardiac systolic function rather than on diastolic function. Expand
Apelin: a potential marker of coronary artery stenosis and atherosclerotic plaque stability in ACS patients.
TLDR
Plasma apelin levels were inversely correlated with the severity of coronary artery stenosis and positively related with the stability of atherosclerotic plaque in humans with acute coronary syndrome. Expand
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