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Colonic drug delivery is intended not only for local treatment in inflammatory bowel disease (IBD) but also for systemic delivery of therapeutics. Intestinal myeloperoxidase (MPO) determination could be used to estimate the average level of inflammation in colon as well as to determine the efficacy of drugs to be used in the treatment of inflammatory bowel(More)
The insect growth regulator, Lufenuron, at concentrations of even multiples of LC90 (determined under laboratory conditions) was tested against the III instar larvae of Aedes aegypti under simulated field conditions. For all concentrations tested, 100 % mortality of the larvae was observed within 24 h of exposure to Lufenuron-treated water. In experiments(More)
The roots and leaves of the plant Butea frondosa were evaluated for ocular anti-inflammatory activity on the subacute model of ocular inflammation in rabbits. The arkas (liquid preparations obtained by distillation of certain liquids or drugs soaked in water, using the Arka-Yantra or any other convenient modern distillation apparatus) were prepared using(More)
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) used in the treatment of rheumatoid arthritis for more than a decade. The high incidence and severity of side effects, which are dose-related and associated with long-term administration, have limited its use. This has led to the search for new delivery systems which can overcome the side effects(More)
Today's modern conceptual aircraft designs exhibit a strong, nonlinear, interdisciplinary coupling and require a multidisciplinary, collaborative approach. Efficient transfer, sharing, and manipulation of aircraft design and analysis data in such a collaborative environment demands a formal structured representation of data. XML, a W3C recommendation, is(More)
BACKGROUND Hypertension (HTN) is a major risk factor contributing to premature mortality from cardiovascular and cerebrovascular disease.To decrease morbidity and mortality from HTN, timely diagnosis of the disease and its complications, urgent treatment and referrals are required. General Practioners (GPs) are the first tier of the health care system in(More)
A new Pareto front approximation method is proposed for multiobjective optimization problems with bound constraints. The method employs a hybrid optimization approach using two derivative free direct search techniques, and intends to solve blackbox simulation based multiob-jective optimization problems where the analytical form of the objectives is not(More)
SUMMARY Computational steering allows scientists to interactively control a numerical experiment and adjust parameters of the computation on-the-fly and explore " what if " analysis. Computational steering effectively reduces computational time, makes research more efficient, and opens up new product design opportunities. There are several problem solving(More)